Protein Info for Rv2942 in Mycobacterium tuberculosis H37Rv

Annotation: Conserved transmembrane transport protein MmpL7

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 750 800 850 920 transmembrane" amino acids 43 to 63 (21 residues), see Phobius details amino acids 212 to 231 (20 residues), see Phobius details amino acids 239 to 259 (21 residues), see Phobius details amino acids 271 to 293 (23 residues), see Phobius details amino acids 313 to 331 (19 residues), see Phobius details amino acids 342 to 364 (23 residues), see Phobius details amino acids 387 to 411 (25 residues), see Phobius details amino acids 761 to 782 (22 residues), see Phobius details amino acids 789 to 811 (23 residues), see Phobius details amino acids 820 to 840 (21 residues), see Phobius details amino acids 864 to 884 (21 residues), see Phobius details amino acids 890 to 913 (24 residues), see Phobius details PF03176: MMPL" amino acids 75 to 382 (308 residues), 236.8 bits, see alignment E=1.7e-74 amino acids 617 to 913 (297 residues), 40.1 bits, see alignment E=1.1e-14

Best Hits

Swiss-Prot: 100% identical to MMPL7_MYCTU: Phthiocerol dimycocerosate exporter MmpL7 (mmpL7) from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)

KEGG orthology group: K06994, putative drug exporter of the RND superfamily (inferred from 100% identity to mtf:TBFG_12956)

Predicted SEED Role

"Transmembrane transport protein MmpL7"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (920 amino acids)

>Rv2942 Conserved transmembrane transport protein MmpL7 (Mycobacterium tuberculosis H37Rv)
MPSPAGRLHRIRYIRLKKSSPDCRATITSGSADGQRRSPRLTNLLVVAAWVAAAVIANLL
LTFTQAEPHDTSPALLPQDAKTAAATSRIAQAFPGTGSNAIAYLVVEGGSTLEPQDQPYY
DAAVGALRADTRHVGSVLDWWSDPVTAPLGTSPDGRSATAMVWLRGEAGTTQAAESLDAV
RSVLRQLPPSEGLRASIVVPAITNDMPMQITAWQSATIVTVAAVIAVLLLLRARLSVRAA
AIVLLTADLSLAVAWPLAAVVRGHDWGTDSVFSWTLAAVLTIGTITAATMLAARLGSDAG
HSAAPTYRDSLPAFALPGACVAIFTGPLLLARTPALHGVGTAGLGVFVALAASLTVLPAL
IALAGASRQLPAPTTGAGWTGRLSLPVSSASALGTAAVLAICMLPIIGMRWGVAENPTRQ
GGAQVLPGNALPDVVVIKSARDLRDPAALIAINQVSHRLVEVPGVRKVESAAWPAGVPWT
DASLSSAAGRLADQLGQQAGSFVPAVTAIKSMKSIIEQMSGAVDQLDSTVNVTLAGARQA
QQYLDPMLAAARNLKNKTTELSEYLETIHTWIVGFTNCPDDVLCTAMRKVIEPYDIVVTG
MNELSTGADRISAISTQTMSALSSAPRMVAQMRSALAQVRSFVPKLETTIQDAMPQIAQA
SAMLKNLSADFADTGEGGFHLSRKDLADPSYRHVRESMFSSDGTATRLFLYSDGQLDLAA
AARAQQLEIAAGKAMKYGSLVDSQVTVGGAAQIAAAVRDALIHDAVLLAVILLTVVALAS
MWRGAVHGAAVGVGVLASYLAALGVSIALWQHLLDRELNALVPLVSFAVLASCGVPYLVA
GIKAGRIADEATGARSKGAVSGRGAVAPLAALGGVFGAGLVLVSGGSFSVLSQIGTVVVL
GLGVLITVQRAWLPTTPGRR