Protein Info for Rv2940c in Mycobacterium tuberculosis H37Rv

Annotation: Probable multifunctional mycocerosic acid synthase membrane-associated Mas

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 200 400 600 800 1000 1200 1400 1600 1800 2000 2111 transmembrane" amino acids 1769 to 1788 (20 residues), see Phobius details PF00109: ketoacyl-synt" amino acids 7 to 255 (249 residues), 325.2 bits, see alignment E=1.9e-100 PF02801: Ketoacyl-synt_C" amino acids 264 to 376 (113 residues), 138.3 bits, see alignment 7.2e-44 PF16197: KAsynt_C_assoc" amino acids 389 to 487 (99 residues), 54.2 bits, see alignment 1.1e-17 PF00698: Acyl_transf_1" amino acids 534 to 851 (318 residues), 399.5 bits, see alignment E=8.1e-123 PF21089: PKS_DH_N" amino acids 896 to 993 (98 residues), 81 bits, see alignment 3.3e-26 PF14765: PS-DH" amino acids 1023 to 1174 (152 residues), 100.7 bits, see alignment 4.1e-32 PF08240: ADH_N" amino acids 1446 to 1507 (62 residues), 23.6 bits, see alignment (E = 2.3e-08) PF00107: ADH_zinc_N" amino acids 1570 to 1696 (127 residues), 78 bits, see alignment 3.8e-25 PF13602: ADH_zinc_N_2" amino acids 1603 to 1741 (139 residues), 78.6 bits, see alignment 5.7e-25 PF08659: KR" amino acids 1765 to 1942 (178 residues), 188 bits, see alignment E=9.2e-59 PF00106: adh_short" amino acids 1768 to 1922 (155 residues), 30.9 bits, see alignment 1.1e-10 PF00550: PP-binding" amino acids 2042 to 2096 (55 residues), 40.2 bits, see alignment (E = 2e-13)

Best Hits

Swiss-Prot: 100% identical to MCAS_MYCBO: Mycocerosic acid synthase (mas) from Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97)

KEGG orthology group: K11628, mycocerosic acid synthase [EC: 2.3.1.111] (inferred from 100% identity to mbt:JTY_2957)

MetaCyc: 100% identical to mycocerosic acid synthase monomer (Mycobacterium tuberculosis variant bovis)
Mycocerosate synthase. [EC: 2.3.1.111]; 2.3.1.111 [EC: 2.3.1.111]; 2.3.1.111 [EC: 2.3.1.111]

Predicted SEED Role

No annotation

MetaCyc Pathways

Isozymes

No predicted isozymes

Use Curated BLAST to search for 2.3.1.111

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (2111 amino acids)

>Rv2940c Probable multifunctional mycocerosic acid synthase membrane-associated Mas (Mycobacterium tuberculosis H37Rv)
MESRVTPVAVIGMGCRLPGGINSPDKLWESLLRGDDLVTEIPPDRWDADDYYDPEPGVPG
RSVSRWGGFLDDVAGFDAEFFGISEREATSIDPQQRLLLETSWEAIEHAGLDPASLAGSS
TAVFTGLTHEDYLVLTTTAGGLASPYVVTGLNNSVASGRIAHTLGLHGPAMTFDTACSSG
LMAVHLACRSLHDGEADLALAGGCAVLLEPHASVAASAQGMLSSTGRCHSFDADADGFVR
SEGCAMVLLKRLPDALRDGNRIFAVVRGTATNQDGRTETLTMPSEDAQVAVYRAALAAAG
VQPETVGVVEAHGTGTPIGDPIEYRSLARVYGAGTPCALGSAKSNMGHSTASAGTVGLIK
AILSLRHGVVPPLLHFNRLPDELSDVETGLFVPQAVTPWPNGNDHTPKRVAVSSFGMSGT
NVHAIVEEAPAEASAPESSPGDAEVGPRLFMLSSTSSDALRQTARQLATWVEEHQDCVAA
SDLAYTLARGRAHRPVRTAVVAANLPELVEGLREVADGDALYDAAVGHGDRGPVWVFSGQ
GSQWAAMGTQLLASEPVFAATIAKLEPVIAAESGFSVTEAITAQQTVTGIDKVQPAVFAV
QVALAATMEQTYGVRPGAVVGHSMGESAAAVVAGALSLEDAARVICRRSKLMTRIAGAGA
MGSVELPAKQVNSELMARGIDDVVVSVVASPQSTVIGGTSDTVRDLIARWEQRDVMAREV
AVDVASHSPQVDPILDDLAAALADIAPMTPKVPYYSATLFDPREQPVCDGAYWVDNLRNT
VQFAAAVQAAMEDGYRVFAELSPHPLLTHAVEQTGRSLDMSVAALAGMRREQPLPHGLRG
LLTELHRAGAALDYSALYPAGRLVDAPLPAWTHARLFIDDDGQEQRAQGACTITVHPLLG
SHVRLTEEPERHVWQGDVGTSVLSWLSDHQVHNVAALPGAAYCEMALAAAAEVFGEAAEV
RDITFEQMLLLDEQTPIDAVASIDAPGVVNFTVETNRDGETTRHATAALRAAEDDCPPPG
YDITALLQAHPHAVNGTAMRESFAERGVTLGAAFGGLTTAHTAEAGAATVLAEVALPASI
RFQQGAYRIHPALLDACFQSVGAGVQAGTATGGLLLPLGVRSLRAYGPTRNARYCYTRLT
KAFNDGTRGGEADLDVLDEHGTVLLAVRGLRMGTGTSERDERDRLVSERLLTLGWQQRAL
PEVGDGEAGSWLLIDTSNAVDTPDMLASTLTDALKSHGPQGTECASLSWSVQDTPPNDQA
GLEKLGSQLRGRDGVVIVYGPRVGDPDEHSLLAGREQVRHLVRITRELAEFEGELPRLFV
VTRQAQIVKPHDSGERANLEQAGLRGLLRVISSEHPMLRTTLIDVDEHTDVERVAQQLLS
GSEEDETAWRNGDWYVARLTPSPLGHEERRTAVLDPDHDGMRVQVRRPGDLQTLEFVASD
RVPPGPGQIEVAVSMSSINFADVLIAFGRFPIIDDREPQLGMDFVGVVTAVGEGVTGHQV
GDRVGGFSEGGCWRTFLTCDANLAVTLPPGLTDEQAITAATAHATAWYGLNDLAQIKAGD
KVLIHSATGGVGQAAISIARAKGAEIFATAGNPAKRAMLRDMGVEHVYDSRSVEFAEQIR
RDTDGYGVDIVLNSLTGAAQRAGLELLAFGGRFVEIGKADVYGNTRLGLFPFRRGLTFYY
LDLALMSVTQPDRVRELLATVFKLTADGVLTAPQCTHYPLAEAADAIRAMSNAEHTGKLV
LDVPRSGRRSVAVTPEQAPLYRRDGSYIITGGLGGLGLFFASKLAAAGCGRIVLTARSQP
NPKARQTIEGLRAAGADIVVECGNIAEPDTADRLVSAATATGLPLRGVLHSAAVVEDATL
TNITDELIDRDWSPKVFGSWNLHRATLGQPLDWFCLFSSGAALLGSPGQGAYAAANSWVD
VFAHWRRAQGLPVSAIAWGAWGEVGRATFLAEGGEIMITPEEGAYAFETLVRHDRAYSGY
IPILGAPWLADLVRRSPWGEMFASTGQRSRGPSKFRMELLSLPQDEWAGRLRRLLVEQAS
VILRRTIDADRSFIEYGLDSLGMLEMRTHVETETGIRLTPKVIATNNTARALAQYLADTL
AEEQAAAPAAS