Protein Info for Rv2939 in Mycobacterium tuberculosis H37Rv

Annotation: Possible conserved polyketide synthase associated protein PapA5

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

Best Hits

Swiss-Prot: 100% identical to PAPA5_MYCTU: Phthiocerol/phthiodiolone dimycocerosyl transferase (papA5) from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)

KEGG orthology group: None (inferred from 100% identity to mra:MRA_2965)

MetaCyc: 100% identical to phenolphthiocerol/phthiocerol/phthiodiolone dimycocerosyl transferase (Mycobacterium tuberculosis H37Rv)
RXN-17258 [EC: 2.3.1.282]; 2.3.1.282 [EC: 2.3.1.282]; 2.3.1.282 [EC: 2.3.1.282]

Predicted SEED Role

No annotation

MetaCyc Pathways

dimycocerosyl triglycosyl phenolphthiocerol biosynthesis (9/11 steps found)
dimycocerosyl phthiocerol biosynthesis (2/4 steps found)

Isozymes

No predicted isozymes

Use Curated BLAST to search for 2.3.1.282

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (422 amino acids)

>Rv2939 Possible conserved polyketide synthase associated protein PapA5 (Mycobacterium tuberculosis H37Rv)
MFPGSVIRKLSHSEEVFAQYEVFTSMTIQLRGVIDVDALSDAFDALLETHPVLASHLEQS
SDGGWNLVADDLLHSGICVIDGTAATNGSPSGNAELRLDQSVSLLHLQLILREGGAELTL
YLHHCMADGHHGAVLVDELFSRYTDAVTTGDPGPITPQPTPLSMEAVLAQRGIRKQGLSG
AERFMSVMYAYEIPATETPAVLAHPGLPQAVPVTRLWLSKQQTSDLMAFGREHRLSLNAV
VAAAILLTEWQLRNTPHVPIPYVYPVDLRFVLAPPVAPTEATNLLGAASYLAEIGPNTDI
VDLASDIVATLRADLANGVIQQSGLHFGTAFEGTPPGLPPLVFCTDATSFPTMRTPPGLE
IEDIKGQFYCSISVPLDLYSCAVYAGQLIIEHHGHIAEPGKSLEAIRSLLCTVPSEYGWI
ME