Protein Info for Rv2935 in Mycobacterium tuberculosis H37Rv

Annotation: Phenolpthiocerol synthesis type-I polyketide synthase PpsE

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 100 200 300 400 500 600 700 800 900 1000 1100 1200 1300 1400 1488 PF00109: ketoacyl-synt" amino acids 6 to 261 (256 residues), 245.5 bits, see alignment E=2.1e-76 PF02801: Ketoacyl-synt_C" amino acids 270 to 389 (120 residues), 144.2 bits, see alignment E=5.4e-46 PF16197: KAsynt_C_assoc" amino acids 392 to 500 (109 residues), 56.5 bits, see alignment 1e-18 PF00698: Acyl_transf_1" amino acids 551 to 864 (314 residues), 168.7 bits, see alignment E=7e-53 PF00550: PP-binding" amino acids 938 to 1000 (63 residues), 52.7 bits, see alignment (E = 1.2e-17) PF00668: Condensation" amino acids 1027 to 1358 (332 residues), 87.9 bits, see alignment E=2e-28

Best Hits

Swiss-Prot: 100% identical to PPSE_MYCTU: Phthiocerol synthesis polyketide synthase type I PpsE (ppsE) from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)

KEGG orthology group: K12444, phenolpthiocerol synthesis type-I polyketide synthase E (inferred from 100% identity to mbo:Mb2960)

MetaCyc: 100% identical to phthiocerol synthase PpsE PKS (Mycobacterium tuberculosis variant bovis)
RXN-17215 [EC: 2.3.1.292]; 2.3.1.292 [EC: 2.3.1.292]; 2.3.1.292 [EC: 2.3.1.292]; 2.3.1.292 [EC: 2.3.1.292]; 2.3.1.292 [EC: 2.3.1.292]

Predicted SEED Role

"Phenolpthiocerol synthesis type-I polyketide synthase PpsE"

MetaCyc Pathways

Isozymes

No predicted isozymes

Use Curated BLAST to search for 2.3.1.292

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (1488 amino acids)

>Rv2935 Phenolpthiocerol synthesis type-I polyketide synthase PpsE (Mycobacterium tuberculosis H37Rv)
VSIPENAIAVVGMAGRFPGAKDVSAFWSNLRRGKESIVTLSEQELRDAGVSDKTLADPAY
VRRAPLLDGIDEFDAGFFGFPPLAAQVLDPQHRLFLQCAWHALEDAGADPARFDGSIGVY
GTSSPSGYLLHNLLSHRDPNAVLAEGLNFDQFSLFLQNDKDFLATRISHAFNLRGPSIAV
QTACSSSLVAVHLACLSLLSGECDMALAGGSSLCIPHRVGYFTSPGSMVSAVGHCRPFDV
RADGTVFGSGVGLVVLKPLAAAIDAGDRIHAVIRGSAINNDGSAKMGYAAPNPAAQADVI
AEAHAVSGIDSSTVSYVECHGTGTPLGDPIEIQGLRAAFEVSQTSRSAPCVLGSVKSNIG
HLEVAAGIAGLIKTILCLKNKALPATLHYTSPNPELRLDQSPFVVQSKYGPWECDGVRRA
GVSSFGVGGTNAHVVLEEAPAEASEVSAHAEPAGPQVILLSAQTAAALGESRTALAAALE
TQDGPRLSDVAYTLARRRKHNVTMAAVVHDREHAATVLRAAEHDNVFVGEAAHDGEHGDR
ADAAPTSDRVVFLFPGQGAQHVGMAKGLYDTEPVFAQHFDTCAAGFRDETGIDLHAEVFD
GTATDLERIDRSQPALFTVEYALAKLVDTFGVRAGAYIGYSTGEYIAATLAGVFDLQTAI
KTVSLRARLMHESPPGAMVAVALGPDDVTQYLPPEVELSAVNDPGNCVVAGPKDQIRALR
QRLTEAGIPVRRVRATHAFHTSAMDPMLGQFQEFLSRQQLRPPRTPLLSNLTGSWMSDQQ
VVDPASWTRQISSPIRFADELDVVLAAPSRILVEVGPGGSLTGSAMRHPKWSTTHRTVRL
MRHPLQDVDDRDTFLRALGELWSAGVEVDWTPRRPAVPHLVSLPGYPFARQRHWVEPNHT
VWAQAPGANNGSPAGTADGSTAATVDAARNGESQTEVTLQRIWSQCLGVSSVDRNANFFD
LGGDSLMAISIAMAAANEGLTITPQDLYEYPTLASLTAAVDASFASSGLAKPPEAQANPA
VPPNVTYFLDRGLRDTGRCRVPLILRLDPKIGLPDIRAVLTAVVNHHDALRLHLVGNDGI
WEQHIAAPAEFTGLSNRSVPNGVAAGSPEERAAVLGILAELLEDQTDPNAPLAAVHIAAA
HGGPHYLCLAIHAMVTDDSSRQILATDIVTAFGQRLAGEEITLEPVSTGWREWSLRCAAL
ATHPAALDTRSYWIENSTKATLWLADALPNAHTAHPPRADELTKLSSTLSVEQTSELDDG
RRRFRRSIQTILLAALGRTIAQTVGEGVVAVELEGEGRSVLRPDVDLRRTVGWFTTYYPV
PLACATGLGALAQLDAVHNTLKSVPHYGIGYGLLRYVYAPTGRVLGAQRTPDIHFRYAGV
IPELPSGDAPVQFDSDMTLPVREPIPGMGHAIELRVYRFGGSLHLDWWYDTRRIPAATAE
ALERTFPLALSALIQEAIAAEHTEHDDSEIVGEPEAGALVDLSSMDAG