Protein Info for Rv2934 in Mycobacterium tuberculosis H37Rv

Annotation: Phenolpthiocerol synthesis type-I polyketide synthase PpsD

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 100 200 300 400 500 600 700 800 900 1000 1100 1200 1300 1400 1500 1600 1700 1827 transmembrane" amino acids 1439 to 1459 (21 residues), see Phobius details PF00109: ketoacyl-synt" amino acids 36 to 285 (250 residues), 335.3 bits, see alignment E=1.5e-103 PF02801: Ketoacyl-synt_C" amino acids 293 to 411 (119 residues), 140.2 bits, see alignment 1.8e-44 PF16197: KAsynt_C_assoc" amino acids 415 to 518 (104 residues), 44.4 bits, see alignment 1.1e-14 PF00698: Acyl_transf_1" amino acids 566 to 873 (308 residues), 335.5 bits, see alignment E=2.2e-103 PF21089: PKS_DH_N" amino acids 910 to 1016 (107 residues), 79.8 bits, see alignment 7.2e-26 PF14765: PS-DH" amino acids 1039 to 1197 (159 residues), 123.1 bits, see alignment E=4.7e-39 PF08659: KR" amino acids 1439 to 1616 (178 residues), 189.8 bits, see alignment E=2.3e-59 PF00106: adh_short" amino acids 1442 to 1588 (147 residues), 38.7 bits, see alignment E=4.2e-13 PF13561: adh_short_C2" amino acids 1449 to 1596 (148 residues), 38.7 bits, see alignment E=4.7e-13 PF00550: PP-binding" amino acids 1715 to 1779 (65 residues), 32.5 bits, see alignment (E = 4.6e-11)

Best Hits

Swiss-Prot: 100% identical to PPSD_MYCTU: Phthiocerol synthesis polyketide synthase type I PpsD (ppsD) from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)

KEGG orthology group: K12443, phenolpthiocerol synthesis type-I polyketide synthase D (inferred from 100% identity to mbt:JTY_2951)

MetaCyc: 100% identical to phthiocerol synthase PpsD PKS (Mycobacterium tuberculosis variant bovis)
RXN-17215 [EC: 2.3.1.292]; 2.3.1.292 [EC: 2.3.1.292]; 2.3.1.292 [EC: 2.3.1.292]; 2.3.1.292 [EC: 2.3.1.292]; 2.3.1.292 [EC: 2.3.1.292]

Predicted SEED Role

"Phenolpthiocerol synthesis type-I polyketide synthase PpsD"

MetaCyc Pathways

Isozymes

No predicted isozymes

Use Curated BLAST to search for 2.3.1.292

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (1827 amino acids)

>Rv2934 Phenolpthiocerol synthesis type-I polyketide synthase PpsD (Mycobacterium tuberculosis H37Rv)
MTSLAERAAQLSPNARAALARELVRAGTTFPTDICEPVAVVGIGCRFPGNVTGPESFWQL
LADGVDTIEQVPPDRWDADAFYDPDPSASGRMTTKWGGFVSDVDAFDADFFGITPREAVA
MDPQHRMLLEVAWEALEHAGIPPDSLSGTRTGVMMGLSSWDYTIVNIERRADIDAYLSTG
TPHCAAVGRIAYLLGLRGPAVAVDTACSSSLVAIHLACQSLRLRETDVALAGGVQLTLSP
FTAIALSKWSALSPTGRCNSFDANADGFVRGEGCGVVVLKRLADAVRDQDRVLAVVRGSA
TNSDGRSNGMTAPNALAQRDVITSALKLADVTPDSVNYVETHGTGTVLGDPIEFESLAAT
YGLGKGQGESPCALGSVKTNIGHLEAAAGVAGFIKAVLAVQRGHIPRNLHFTRWNPAIDA
SATRLFVPTESAPWPAAAGPRRAAVSSFGLSGTNAHVVVEQAPDTAVAAAGGMPYVSALN
VSGKTAARVASAAAVLADWMSGPGAAAPLADVAHTLNRHRARHAKFATVIARDRAEAIAG
LRALAAGQPRVGVVDCDQHAGGPGRVFVYSGQGSQWASMGQQLLANEPAFAKAVAELDPI
FVDQVGFSLQQTLIDGDEVVGIDRIQPVLVGMQLALTELWRSYGVIPDAVIGHSMGEVSA
AVVAGALTPEQGLRVITTRSRLMARLSGQGAMALLELDADAAEALIAGYPQVTLAVHASP
RQTVIAGPPEQVDTVIAAVATQNRLARRVEVDVASHHPIIDPILPELRSALADLTPQPPS
IPIISTTYESAQPVADADYWSANLRNPVRFHQAVTAAGVDHNTFIEISPHPVLTHALTDT
LDPDGSHTVMSTMNRELDQTLYFHAQLAAVGVAASEHTTGRLVDLPPTPWHHQRFWVTDR
SAMSELAATHPLLGAHIEMPRNGDHVWQTDVGTEVCPWLADHKVFGQPIMPAAGFAEIAL
AAASEALGTAADAVAPNIVINQFEVEQMLPLDGHTPLTTQLIRGGDSQIRVEIYSRTRGG
EFCRHATAKVEQSPRECAHAHPEAQGPATGTTVSPADFYALLRQTGQHHGPAFAALSRIV
RLADGSAETEISIPDEAPRHPGYRLHPVVLDAALQSVGAAIPDGEIAGSAEASYLPVSFE
TIRVYRDIGRHVRCRAHLTNLDGGTGKMGRIVLINDAGHIAAEVDGIYLRRVERRAVPLP
LEQKIFDAEWTESPIAAVPAPEPAAETTRGSWLVLADATVDAPGKAQAKSMADDFVQQWR
SPMRRVHTADIHDESAVLAAFAETAGDPEHPPVGVVVFVGGASSRLDDELAAARDTVWSI
TTVVRAVVGTWHGRSPRLWLVTGGGLSVADDEPGTPAAASLKGLVRVLAFEHPDMRTTLV
DLDITQDPLTALSAELRNAGSGSRHDDVIAWRGERRFVERLSRATIDVSKGHPVVRQGAS
YVVTGGLGGLGLVVARWLVDRGAGRVVLGGRSDPTDEQCNVLAELQTRAEIVVVRGDVAS
PGVAEKLIETARQSGGQLRGVVHAAAVIEDSLVFSMSRDNLERVWAPKATGALRMHEATA
DCELDWWLGFSSAASLLGSPGQAAYACASAWLDALVGWRRASGLPAAVINWGPWSEVGVA
QALVGSVLDTISVAEGIEALDSLLAADRIRTGVARLRADRALVAFPEIRSISYFTQVVEE
LDSAGDLGDWGGPDALADLDPGEARRAVTERMCARIAAVMGYTDQSTVEPAVPLDKPLTE
LGLDSLMAVRIRNGARADFGVEPPVALILQGASLHDLTADLMRQLGLNDPDPALNNADTI
RDRARQRAAARHGAAMRRRPKPEVQGG