Protein Info for Rv2933 in Mycobacterium tuberculosis H37Rv

Annotation: Phenolpthiocerol synthesis type-I polyketide synthase PpsC

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 200 400 600 800 1000 1200 1400 1600 1800 2000 2188 transmembrane" amino acids 1803 to 1822 (20 residues), see Phobius details amino acids 2117 to 2132 (16 residues), see Phobius details PF00109: ketoacyl-synt" amino acids 35 to 288 (254 residues), 326.1 bits, see alignment E=1.1e-100 PF02801: Ketoacyl-synt_C" amino acids 296 to 413 (118 residues), 140.6 bits, see alignment 1.6e-44 PF00698: Acyl_transf_1" amino acids 572 to 890 (319 residues), 361.5 bits, see alignment E=3.3e-111 PF21089: PKS_DH_N" amino acids 928 to 1029 (102 residues), 74.4 bits, see alignment 4.2e-24 PF14765: PS-DH" amino acids 1058 to 1219 (162 residues), 82.4 bits, see alignment 1.8e-26 PF08240: ADH_N" amino acids 1485 to 1544 (60 residues), 26.6 bits, see alignment (E = 3e-09) PF00107: ADH_zinc_N" amino acids 1607 to 1715 (109 residues), 79.3 bits, see alignment 1.7e-25 PF13602: ADH_zinc_N_2" amino acids 1639 to 1778 (140 residues), 85.6 bits, see alignment 4.2e-27 PF08659: KR" amino acids 1802 to 1980 (179 residues), 211.3 bits, see alignment E=7e-66 PF00106: adh_short" amino acids 1805 to 1961 (157 residues), 45.6 bits, see alignment 3.9e-15 PF13561: adh_short_C2" amino acids 1812 to 1960 (149 residues), 39.9 bits, see alignment 2.4e-13 PF00550: PP-binding" amino acids 2077 to 2141 (65 residues), 45.4 bits, see alignment (E = 5.3e-15)

Best Hits

Swiss-Prot: 100% identical to PPSC_MYCTU: Phthiocerol synthesis polyketide synthase type I PpsC (ppsC) from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)

KEGG orthology group: K12442, phenolpthiocerol synthesis type-I polyketide synthase C (inferred from 100% identity to mbt:JTY_2950)

MetaCyc: 100% identical to phthiocerol synthase PpsC PKS (Mycobacterium tuberculosis variant bovis)
RXN-17215 [EC: 2.3.1.292]; 2.3.1.292 [EC: 2.3.1.292]; 2.3.1.292 [EC: 2.3.1.292]; 2.3.1.292 [EC: 2.3.1.292]; 2.3.1.292 [EC: 2.3.1.292]

Predicted SEED Role

"Phenolpthiocerol synthesis type-I polyketide synthase PpsC"

MetaCyc Pathways

Isozymes

No predicted isozymes

Use Curated BLAST to search for 2.3.1.292

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (2188 amino acids)

>Rv2933 Phenolpthiocerol synthesis type-I polyketide synthase PpsC (Mycobacterium tuberculosis H37Rv)
MTAATPDRRAIITEALHKIDDLTARLEIAEKSSSEPIAVIGMGCRFPGGVNNPEQFWDLL
CAGRSGIVRVPAQRWDADAYYCDDHTVPGTICSTEGGFLTSWQPDEFDAEFFSISPREAA
AMDPQQRLLIEVAWEALEDAGVPQHTIRGTQTSVFVGVTAYDYMLTLAGRLRPVDLDAYI
PTGNSANFAAGRLAYILGARGPAVVIDTACSSSLVAVHLACQSLRGRESDMALVGGTNLL
LSPGPSIACSRWGMLSPEGRCKTFDASADGYVRGEGAAVVVLKRLDDAVRDGNRILAVVR
GSAVNQDGASSGVTVPNGPAQQALLAKALTSSKLTAADIDYVEAHGTGTPLGDPIELDSL
SKVFSDRAGSDQLVIGSVKTNLGHLEAAAGVAGLMKAVLAVHNGYIPRHLNFHQLTPHAS
EAASRLRIAADGIDWPTTGRPRRAGVSSFGVSGTNAHVVIEQAPDPMAAAGTEPQRGPVP
AVSTLVVFGKTAPRVAATASVLADWLDGPGAAVPLADVAHTLNHHRARQTRFGTVAAVDR
RQAVIGLRALAAGQSAPGVVAPREGSIGGGTVFVYSGRGSQWAGMGRQLLADEPAFAAAI
AELEPEFVAQGGFSLRDVIAGGKELVGIEQIQLGLIGMQLALTALWRSYGVTPDAVIGHS
MGEVAAAVVAGALTPAQGLRVTAVRSRLMAPLSGQGTMALLELDAEATEALIADYPEVSL
GIYASPRQTVISGPPLLIDELIDKVRQQNGFATRVNIEVAPHNPAMDALQPAMRSELADL
TPQPPTIPIISTTYADLGISLGSGPRFDAEHWATNMRNPVRFHQAIAHAGADHHTFIEIS
AHPLLTHSISDTLRASYDVDNYLSIGTLQRDAHDTLEFHTNLNTTHTTHPPQTPHPPEPH
PVLPTTPWQHTQHWITATSAAYHRPDTHPLLGVGVTDPTNGTRVWESELDPDLLWLADHV
IDDLVVLPGAAYAEIALAAATDTFAVEQDQPWMISELDLRQMLHVTPGTVLVTTLTGDEQ
RCQVEIRTRSGSSGWTTHATATVARAEPLAPLDHEGQRREVTTADLEDQLDPDDLYQRLR
GAGQQHGPAFQGIVGLAVTQAGVARAQVRLPASARTGSREFMLHPVMMDIALQTLGATRT
ATDLAGGQDARQGPSSNSALVVPVRFAGVHVYGDITRGVRAVGSLAAAGDRLVGEVVLTD
ANGQPLLVVDEVEMAVLGSGSGATELTNRLFMLEWEPAPLEKTAEATGALLLIGDPAAGD
PLLPALQSSLRDRITDLELASAADEATLRAAISRTSWDGIVVVCPPRANDESMPDEAQLE
LARTRTLLVASVVETVTRMGARKSPRLWIVTRGAAQFDAGESVTLAQTGLRGIARVLTFE
HSELNTTLVDIEPDGTGSLAALAEELLAGSEADEVALRDGQRYVNRLVPAPTTTSGDLAA
EARHQVVNLDSSGASRAAVRLQIDQPGRLDALNVHEVKRGRPQGDQVEVRVVAAGLNFSD
VLKAMGVYPGLDGAAPVIGGECVGYVTAIGDEVDGVEVGQRVIAFGPGTFGTHLGTIADL
VVPIPDTLADNEAATFGVAYLTAWHSLCEVGRLSPGERVLIHSATGGVGMAAVSIAKMIG
ARIYTTAGSDAKREMLSRLGVEYVGDSRSVDFADEILELTDGYGVDVVLNSLAGEAIQRG
VQILAPGGRFIELGKKDVYADASLGLAALAKSASFSVVDLDLNLKLQPARYRQLLQHILQ
HVADGKLEVLPVTAFSLHDAADAFRLMASGKHTGKIVISIPQHGSIEAIAAPPPLPLVSR
DGGYLIVGGMGGLGFVVARWLAEQGAGLIVLNGRSAPSDEVAAAIAELNASGSRIEVITG
DITEPDTAERLVRAVEDAGFRLAGVVHSAMVLADEIVLNMTDSAARRVFAPKVTGSWRLH
VATAARDVDWWLTFSSAAALLGTPGQGAYAAANSWVDGLVAHRRSAGLPAVGINWGPWAD
VGRAQFFKDLGVEMINAEQGLAAMQAVLTADRGRTGVFSLDARQWFQSFPAVAGSSLFAK
LHDSAARKSGQRRGGGAIRAQLDALDAAERPGHLASAIADEIRAVLRSGDPIDHHRPLET
LGLDSLMGLELRNRLEASLGITLPVALVWAYPTISDLATALCERMDYATPAAAQEISDTE
PELSDEEMDLLADLVDASELEAATRGES