Protein Info for Rv2894c in Mycobacterium tuberculosis H37Rv

Annotation: Probable integrase/recombinase XerC

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 298 PF02899: Phage_int_SAM_1" amino acids 5 to 87 (83 residues), 82.6 bits, see alignment E=1.9e-27 PF00589: Phage_integrase" amino acids 109 to 284 (176 residues), 171.8 bits, see alignment E=1.2e-54

Best Hits

Swiss-Prot: 100% identical to XERC_MYCBO: Tyrosine recombinase XerC (xerC) from Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97)

KEGG orthology group: K03733, integrase/recombinase XerC (inferred from 100% identity to mbb:BCG_2915c)

Predicted SEED Role

"Tyrosine recombinase XerC"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (298 amino acids)

>Rv2894c Probable integrase/recombinase XerC (Mycobacterium tuberculosis H37Rv)
VQAILDEFDEYLALQCGRSVHTRRAYLGDLRSLFAFLADRGSSLDALTLSVLRSWLAATA
GAGAARTTLARRTSAVKAFTAWAVRRGLLAGDPAARLQVPKARRTLPAVLRQDQALRAMA
AAESGAEQGDPLALRDRLIVELLYATGIRVSELCGLDVDDIDTGHRLVRVLGKGNKQRTV
PFGQPAADALHAWLVDGRRALVTAESGHALLLGARGRRLDVRQARTAVHQTVAAVDGAPD
MGPHGLRHSAATHLLEGGADLRVVQELLGHSSLATTQLYTHVAVARLRAVHERAHPRA