Protein Info for Rv2887 in Mycobacterium tuberculosis H37Rv

Annotation: Probable transcriptional regulatory protein

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 139 PF12802: MarR_2" amino acids 31 to 89 (59 residues), 40.3 bits, see alignment E=4.2e-14 PF01047: MarR" amino acids 33 to 90 (58 residues), 54 bits, see alignment E=1.9e-18 PF13412: HTH_24" amino acids 41 to 77 (37 residues), 23.4 bits, see alignment E=5.4e-09

Best Hits

Swiss-Prot: 100% identical to Y2887_MYCTU: Uncharacterized HTH-type transcriptional regulator Rv2887 (Rv2887) from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)

KEGG orthology group: None (inferred from 99% identity to mtf:TBFG_12901)

Predicted SEED Role

"Transcriptional regulator, MarR family"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (139 amino acids)

>Rv2887 Probable transcriptional regulatory protein (Mycobacterium tuberculosis H37Rv)
MGLADDAPLGYLLYRVGAVLRPEVSAALSPLGLTLPEFVCLRMLSQSPGLSSAELARHAS
VTPQAMNTVLRKLEDAGAVARPASVSSGRSLPATLTARGRALAKRAEAVVRAADARVLAR
LTAPQQREFKRMLEKLGSD