Protein Info for Rv2838c in Mycobacterium tuberculosis H37Rv

Annotation: Probable ribosome-binding factor a RbfA (P15B protein)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 183 TIGR00082: ribosome-binding factor A" amino acids 1 to 114 (114 residues), 59 bits, see alignment E=3.2e-20 PF02033: RBFA" amino acids 6 to 113 (108 residues), 88.5 bits, see alignment E=1.7e-29

Best Hits

Swiss-Prot: 100% identical to RBFA_MYCTU: Ribosome-binding factor A (rbfA) from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)

KEGG orthology group: K02834, ribosome-binding factor A (inferred from 100% identity to mra:MRA_2861)

Predicted SEED Role

"Ribosome-binding factor A" in subsystem NusA-TFII Cluster

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (183 amino acids)

>Rv2838c Probable ribosome-binding factor a RbfA (P15B protein) (Mycobacterium tuberculosis H37Rv)
MADAARARRLAKRIAAIVASAIEYEIKDPGLAGVTITDAKVTADLHDATVYYTVMGRTLH
DEPNCAGAAAALERAKGVLRTKVGAGTGVRFTPTLTFTLDTISDSVHRMDELLARARAAD
ADLARVRVGAKPAGEADPYRDNGSVAQSPAPGGLGIRTSDGPEAVEAPLTCGGDTGDDDR
PKE