Protein Info for Rv2745c in Mycobacterium tuberculosis H37Rv

Annotation: Transcriptional regulatory protein ClgR

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 112 transmembrane" amino acids 52 to 71 (20 residues), see Phobius details PF13560: HTH_31" amino acids 10 to 64 (55 residues), 37 bits, see alignment E=3.4e-13 PF01381: HTH_3" amino acids 13 to 65 (53 residues), 41.9 bits, see alignment E=8.4e-15

Best Hits

Swiss-Prot: 100% identical to CLGR_MYCTU: Transcriptional regulator ClgR (clgR) from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)

KEGG orthology group: None (inferred from 100% identity to mtu:Rv2745c)

Predicted SEED Role

"FIG01123282: hypothetical protein"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (112 amino acids)

>Rv2745c Transcriptional regulatory protein ClgR (Mycobacterium tuberculosis H37Rv)
MAALVREVVGDVLRGARMSQGRTLREVSDSARVSLGYLSEIERGRKEPSSELLSAICTAL
QLPLSVVLIDAGERMARQERLARATPAGRATGATIDASTKVVIAPVVSLAVA