Protein Info for Rv2690c in Mycobacterium tuberculosis H37Rv

Annotation: Probable conserved integral membrane alanine and valine and leucine rich protein

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 657 transmembrane" amino acids 31 to 47 (17 residues), see Phobius details amino acids 53 to 81 (29 residues), see Phobius details amino acids 105 to 130 (26 residues), see Phobius details amino acids 147 to 164 (18 residues), see Phobius details amino acids 173 to 197 (25 residues), see Phobius details amino acids 218 to 241 (24 residues), see Phobius details amino acids 261 to 282 (22 residues), see Phobius details amino acids 319 to 341 (23 residues), see Phobius details amino acids 370 to 390 (21 residues), see Phobius details amino acids 397 to 418 (22 residues), see Phobius details amino acids 441 to 459 (19 residues), see Phobius details amino acids 465 to 483 (19 residues), see Phobius details amino acids 624 to 639 (16 residues), see Phobius details PF13520: AA_permease_2" amino acids 60 to 455 (396 residues), 75 bits, see alignment E=2.9e-25

Best Hits

KEGG orthology group: None (inferred from 100% identity to mra:MRA_2718)

Predicted SEED Role

"PROBABLE CONSERVED INTEGRAL MEMBRANE ALANINE AND VALINE AND LEUCINE RICH PROTEIN"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (657 amino acids)

>Rv2690c Probable conserved integral membrane alanine and valine and leucine rich protein (Mycobacterium tuberculosis H37Rv)
VSKLSTAARRLLIGRPFRSDRLSHTLLPKRIALPVFASDAMSSIAYAPEEIFLVLSVAGL
AAYSMAPLIGLAVAAVLLVVVSSYRQNVHAYPSGGGDYEVVTTNLGATGGLVVASALMVD
YVLTVAVSISSAASNIGSVSPFVYEHKVLFAVGAIVLIMAMNLRGVRESGLAFAIPTYAF
IAGIGTMLVWGLFRIFVLGNPVRAESAAFEMHAEHGQIVGFALVFLVARSFSSGCAALTG
VEAISNGVPAFQKPKSRNAATTLLMLGIIAVSMFMGMIVLAVETGVQVVDDPDTQLTGAP
PGYQQKTLVAQLAQAVFGGFYLGFLLIAAVTALILVLAANTAFNGFPVLGSVLAQHSYLP
RQLHTRGDRLAFSNGILFLAAAAIGAVVAFRAELTALIQLYIVGVFISFTMSQVGMVRHW
TRLLSAETDPRARRAMLRSRAVNTVGFVSTGTVLLIVLVTKFLAGAWIAIVAMGGFFMMM
KLIHRHYDAVNRELAEQAEEAEITLPSRNHAVVLVSKLHLPTLRALTYARATRPDVLEAV
TVNVDDAETRELVRQWQDSDVSVPLKVIASPYREITRPVLDYVKRVSKESPRTVVTVFIP
EYVVGRWWEQLLHNQSALRLKGRLLFMPGVMVTSVPWQLTSSERIKTLQPHAAPGDT