Protein Info for Rv2626c in Mycobacterium tuberculosis H37Rv

Annotation: Hypoxic response protein 1 Hrp1

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 143 PF00571: CBS" amino acids 4 to 55 (52 residues), 48.7 bits, see alignment E=3.8e-17 amino acids 71 to 124 (54 residues), 48.6 bits, see alignment E=4.1e-17

Best Hits

Swiss-Prot: 100% identical to HRP1_MYCTU: Hypoxic response protein 1 (hrp1) from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)

KEGG orthology group: None (inferred from 100% identity to mbt:JTY_2647)

Predicted SEED Role

"CBS domain protein"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (143 amino acids)

>Rv2626c Hypoxic response protein 1 Hrp1 (Mycobacterium tuberculosis H37Rv)
MTTARDIMNAGVTCVGEHETLTAAAQYMREHDIGALPICGDDDRLHGMLTDRDIVIKGLA
AGLDPNTATAGELARDSIYYVDANASIQEMLNVMEEHQVRRVPVISEHRLVGIVTEADIA
RHLPEHAIVQFVKAICSPMALAS