Protein Info for Rv2606c in Mycobacterium tuberculosis H37Rv
Annotation: Possible pyridoxine biosynthesis protein SnzP
These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.
Protein Families and Features
Best Hits
Swiss-Prot: 100% identical to PDXS_MYCTO: Pyridoxal 5'-phosphate synthase subunit PdxS (pdxS) from Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)
KEGG orthology group: K06215, pyridoxine biosynthesis protein [EC: 4.-.-.-] (inferred from 100% identity to mtf:TBFG_12625)MetaCyc: 70% identical to pyridoxal 5'-phosphate synthase (Arabidopsis thaliana col)
RXN-11322 [EC: 4.3.3.6]
Predicted SEED Role
"Pyridoxine biosynthesis glutamine amidotransferase, synthase subunit (EC 2.4.2.-)" in subsystem Pyridoxin (Vitamin B6) Biosynthesis (EC 2.4.2.-)
MetaCyc Pathways
- L-asparagine biosynthesis III (tRNA-dependent) (4/4 steps found)
- glutaminyl-tRNAgln biosynthesis via transamidation (4/4 steps found)
- ammonia assimilation cycle III (3/3 steps found)
- L-glutamate biosynthesis I (2/2 steps found)
- L-glutamine degradation I (1/1 steps found)
- pyridoxal 5'-phosphate biosynthesis II (1/1 steps found)
- L-citrulline biosynthesis (6/8 steps found)
- superpathway of L-citrulline metabolism (8/12 steps found)
- L-glutamate and L-glutamine biosynthesis (4/7 steps found)
KEGG Metabolic Maps
- Biosynthesis of alkaloids derived from histidine and purine
- Biosynthesis of plant hormones
- Biosynthesis of type II polyketide backbone
- Photosynthesis - antenna proteins
- Porphyrin and chlorophyll metabolism
- Purine metabolism
- Vitamin B6 metabolism
Isozymes
Compare fitness of predicted isozymes for: 2.4.2.-
Use Curated BLAST to search for 2.4.2.- or 4.-.-.- or 4.3.3.6
Sequence Analysis Tools
PaperBLAST (search for papers about homologs of this protein)
Search CDD (the Conserved Domains Database, which includes COG and superfam)
Predict protein localization: PSORTb (Gram-negative bacteria)
Predict transmembrane helices and signal peptides: Phobius
Check the current SEED with FIGfam search
Find homologs in fast.genomics or the ENIGMA genome browser
Find the best match in UniProt
Protein Sequence (299 amino acids)
>Rv2606c Possible pyridoxine biosynthesis protein SnzP (Mycobacterium tuberculosis H37Rv) MDPAGNPATGTARVKRGMAEMLKGGVIMDVVTPEQARIAEGAGAVAVMALERVPADIRAQ GGVSRMSDPDMIEGIIAAVTIPVMAKVRIGHFVEAQILQTLGVDYIDESEVLTPADYAHH IDKWNFTVPFVCGATNLGEALRRISEGAAMIRSKGEAGTGDVSNATTHMRAIGGEIRRLT SMSEDELFVAAKELQAPYELVAEVARAGKLPVTLFTAGGIATPADAAMMMQLGAEGVFVG SGIFKSGAPEHRAAAIVKATTFFDDPDVLAKVSRGLGEAMVGINVDEIAVGHRLAQRGW