Protein Info for Rv2566 in Mycobacterium tuberculosis H37Rv

Annotation: Long conserved protein

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 100 200 300 400 500 600 700 800 900 1000 1140 transmembrane" amino acids 877 to 894 (18 residues), see Phobius details PF08379: Bact_transglu_N" amino acids 33 to 109 (77 residues), 81.1 bits, see alignment 1.2e-26 PF01841: Transglut_core" amino acids 166 to 284 (119 residues), 58.8 bits, see alignment E=9e-20 PF09899: DUF2126" amino acids 314 to 1133 (820 residues), 1158.6 bits, see alignment E=0

Best Hits

Predicted SEED Role

"Large protein containing transglutaminase-like domain"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (1140 amino acids)

>Rv2566 Long conserved protein (Mycobacterium tuberculosis H37Rv)
VPLRPTQVSGTGRTRCAGRSGVISSAAMSIKVALEHRTSYTFDRLVRVYPHIVRLRPAPH
SRTSIEAYSLRIEPADHFINWQQDALGNFLARLVFPNPMRQLRITVGLIADLKVINPFDF
FIEDWAEIWPCAGMAYPKALADDLRPYLRPVDEDGDGSGPGELTQAWVRNFTVPDGTRTI
DFLVALNRAINADVGYCVRMEPGVQTPDFTLRTGVGSCRDSAWLLVSILRQFGLAARFVS
GYLVQLASDIEALDGPSGPAADFTDLHAWAEAYIPGAGWIGLDPTSGLLAGEGHIPLAAT
PHPASAAPISGGTDVCDTVLEFSNTVTRVHEDPRVTLPYTDESWKTICEVGQRVDERLAA
ADVRLTVGGEPTFVSVDNQVAEEWRTAADGPHKRERASDLAARLKAVWAPQGLIHRGQGR
WYPGEPLPRWQIALYWRTDGRPLWTNDALLADPWGAPPADPVDDDAAYRVLAGIADGLGL
PISQVRPAYEDPLSRLAAAVRMPAGDPVESGDDLGCDTNPDTPTGRAALLARLDEAITSP
AAYVLPLHRRDDGQGWASANWRLRRGRIVLLEGDSPAGLRLPLDSISWRPPRASFDADPV
AVRSTLPAELHTDRAVVEDPETAPTTALVAEVRGGLVHIFLPPTDALEHFIDLVARVEAA
ATTANCPVVIEGYGPPPDPRLTSTTITPDPGVIEVNIAPTASFAEQRQQLETLYQQARLA
RLTTEAFDVDGTHGGTGGGNHITLGGVTPADSPLLRRPDLLVSLLTYWQRHPSLSYLFAG
RFVGTTSQAPRVDEGRAEALYELEIAFAEILRLSPSSGGGRPQPWVTDRALRHLLTDITG
NTHRAEFCIDKLYSPDSARGRLGLLELRGFEMPPHLHMAMVQSLLVRSLVAWFWDQPLRA
PLIRHGANLHGRYLLPHFLIHDIADVAADLRAHGIAFETSWLDPFTEFRFPRIGTAVFDG
IEIELRGAIEPWHTLGEEATAAGTARYVDSSVERIQVRIIGADRHRYVVTCNGYPMPLLA
TDNPDIHVGGVRFKAWQPPSALHPTITVDGPLRFELIDIATATSCGGCTYHVAHPGGRAY
DEPPVNAVEAEARRARRFEATGFTPGKLDLSDIREKQARISTDIGAPGILDLRRVRTVQQ