Protein Info for Rv2485c in Mycobacterium tuberculosis H37Rv

Annotation: Probable carboxylesterase LipQ

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 421 PF00135: COesterase" amino acids 154 to 262 (109 residues), 45.5 bits, see alignment E=1.4e-15 PF20434: BD-FAE" amino acids 166 to 359 (194 residues), 164.1 bits, see alignment E=8.9e-52 PF07859: Abhydrolase_3" amino acids 176 to 379 (204 residues), 77.5 bits, see alignment E=3.3e-25 PF00326: Peptidase_S9" amino acids 222 to 383 (162 residues), 50.2 bits, see alignment E=6.3e-17

Best Hits

KEGG orthology group: K01175, [EC: 3.1.-.-] (inferred from 100% identity to mtf:TBFG_12506)

Predicted SEED Role

"LipQ"

Isozymes

Compare fitness of predicted isozymes for: 3.1.-.-

Use Curated BLAST to search for 3.1.-.-

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (421 amino acids)

>Rv2485c Probable carboxylesterase LipQ (Mycobacterium tuberculosis H37Rv)
MHIASVTSRCSRAGAEALRQGAQLAADARDTCRAGALLLRGSPCAIGWVAGWLSAEFPAR
VVTGHALSRISPRSIGRFGTSWAAQRADQILHAALVDAFGPDFRDLVWHPTGEQSEAARR
SGLLNLPHIPGPHRRYAAQTSDIPYGPGGRENLLDIWRRPDLAPGRRAPVLIQVPGGAWT
INGKRPQAYPLMSRMVELGWICVSINYSKSPRCTWPAHIVDVKRAIAWVRENIADYGGDP
DFITITGGSAGAHLAALAALSANDPALQPGFESADTAVQAAAPYYGVYDLTNAENMHEMM
MPFLEHFVMRSRYVDNPGLFKAASPISYVHSEAPPFFVLHGEKDPMVPSAQSRAFSAALR
DAGAATVSYAELPNAHHAFDLAATVRSRMVAEAVSDFLGVIYGRRMGARKGSLALSSPPA
S