Protein Info for Rv2442c in Mycobacterium tuberculosis H37Rv

Annotation: 50S ribosomal protein L21 RplU

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 104 TIGR00061: ribosomal protein bL21" amino acids 5 to 103 (99 residues), 82.7 bits, see alignment E=1e-27 PF00829: Ribosomal_L21p" amino acids 5 to 103 (99 residues), 109.8 bits, see alignment E=3.4e-36

Best Hits

Swiss-Prot: 100% identical to RL21_MYCBO: 50S ribosomal protein L21 (rplU) from Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97)

KEGG orthology group: K02888, large subunit ribosomal protein L21 (inferred from 100% identity to mtb:TBMG_01530)

Predicted SEED Role

"LSU ribosomal protein L21p" in subsystem Ribosome LSU bacterial

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (104 amino acids)

>Rv2442c 50S ribosomal protein L21 RplU (Mycobacterium tuberculosis H37Rv)
MMATYAIVKTGGKQYKVAVGDVVKVEKLESEQGEKVSLPVALVVDGATVTTDAKALAKVA
VTGEVLGHTKGPKIRIHKFKNKTGYHKRQGHRQQLTVLKVTGIA