Protein Info for Rv2437 in Mycobacterium tuberculosis H37Rv

Annotation: Conserved transmembrane protein

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 139 transmembrane" amino acids 16 to 37 (22 residues), see Phobius details amino acids 72 to 99 (28 residues), see Phobius details PF04191: PEMT" amino acids 21 to 116 (96 residues), 43.3 bits, see alignment E=4.3e-15 PF04140: ICMT" amino acids 29 to 113 (85 residues), 43.2 bits, see alignment E=4.3e-15

Best Hits

KEGG orthology group: None (inferred from 99% identity to mtb:TBMG_01535)

Predicted SEED Role

"Putative protein-S-isoprenylcysteine methyltransferase"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (139 amino acids)

>Rv2437 Conserved transmembrane protein (Mycobacterium tuberculosis H37Rv)
VLQRTNVVQPLNTLRMVWIQVAGIIPATAGIAATVYAQLAMGDSWRIGVDEQENTTLVRT
GPFKWVRHPIYTAMMAFGLGLLLVTPNLVALAGFILLVATLEVHVRRVEEPYLLRTHSAV
YRGYTASVGRFVPGVGLIR