Protein Info for Rv2426c in Mycobacterium tuberculosis H37Rv

Annotation: Conserved hypothetical protein

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 291 PF07728: AAA_5" amino acids 46 to 194 (149 residues), 42.9 bits, see alignment E=7.3e-15 PF07724: AAA_2" amino acids 47 to 190 (144 residues), 32.2 bits, see alignment E=1.6e-11 PF00004: AAA" amino acids 47 to 194 (148 residues), 39.9 bits, see alignment E=8.4e-14

Best Hits

KEGG orthology group: None (inferred from 99% identity to mbo:Mb2450c)

MetaCyc: 51% identical to CoxD sulfurtransferase monomer (Afipia carboxidovorans)
RXN-21549

Predicted SEED Role

"MoxR-like ATPases"

MetaCyc Pathways

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (291 amino acids)

>Rv2426c Conserved hypothetical protein (Mycobacterium tuberculosis H37Rv)
VTVPARPTPLFADIADVSRRLAETGYLPDTATATAVFLADRLGKPLLVEGPAGVGKTELA
RAVAQATGSGLVRLQCYEGVDEARALYEWNHAKQILRIQAGSGDWEATKTDVFSEEFLLQ
RPLLTAIRRTEPTVLLIDETDKADIEIEGLLLEVLSDFAVTVPELGTLTATRAPFVLLTS
NATRELSEALKRRCLYLHIDFPTPELERRILLSRVPELPEHFAEELVRIIGVLRGMQLKK
VPSIAETIDWGRTVLALGLDTIDDAVVAATLGVVLKHQSDQQRATGELRLN