Protein Info for Rv2339 in Mycobacterium tuberculosis H37Rv

Annotation: Probable conserved transmembrane transport protein MmpL9

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 750 800 850 900 962 transmembrane" amino acids 25 to 45 (21 residues), see Phobius details amino acids 200 to 218 (19 residues), see Phobius details amino acids 225 to 247 (23 residues), see Phobius details amino acids 255 to 278 (24 residues), see Phobius details amino acids 300 to 322 (23 residues), see Phobius details amino acids 334 to 360 (27 residues), see Phobius details amino acids 381 to 403 (23 residues), see Phobius details amino acids 769 to 788 (20 residues), see Phobius details amino acids 795 to 818 (24 residues), see Phobius details amino acids 825 to 847 (23 residues), see Phobius details amino acids 867 to 890 (24 residues), see Phobius details amino acids 904 to 931 (28 residues), see Phobius details TIGR00833: transport protein" amino acids 27 to 934 (908 residues), 1034 bits, see alignment E=0 PF03176: MMPL" amino acids 59 to 387 (329 residues), 409.7 bits, see alignment E=4e-127 amino acids 607 to 942 (336 residues), 357.6 bits, see alignment E=2.9e-111

Best Hits

Swiss-Prot: 100% identical to MMPL9_MYCTU: Probable transport protein MmpL9 (mmpL9) from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)

KEGG orthology group: K06994, putative drug exporter of the RND superfamily (inferred from 100% identity to mbo:Mb2367)

Predicted SEED Role

No annotation

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (962 amino acids)

>Rv2339 Probable conserved transmembrane transport protein MmpL9 (Mycobacterium tuberculosis H37Rv)
MVPGEVHMSDTPSGPHPIIPRTIRLAAIPILLCWLGFTVFVSVAVPPLEAIGETRAVAVA
PDDAQSMRAMRRAGKVFNEFDSNSIAMVVLESDQPLGEKAHRYYDHLVDTLVLDQSHIQH
IQDFWRDPLTAAGAVSADGKAAYVQLYLAGNMGEALANESVEAVRKIVANSTPPEGIRTY
VTGPAALFADQIAAGDRSMKLITGLTFAVITVLLLLVYRSIATTLLILPMVFIGLGATRG
TIAFLGYHGMVGLSTFVVNILTALAIAAGTDYAIFLVGRYQEARHIGQNREASFYTMYRG
TANVILGSGLTIAGATYCLSFARLTLFHTMGPPLAIGMLVSVAAALTLAPAIIAIAGRFG
LLDPKRRLKTRGWRRVGTAVVRWPGPILATSVALALVGLLALPGYRPGYNDRYYLRAGTP
VNRGYAAADRHFGPARMNPEMLLVESDQDMRNPAGMLVIDKIAKEVLHVSGVERVQAITR
PQGVPLEHASIPFQISMMGATQTMSLPYMRERMADMLTMSDEMLVAINSMEQMLDLVQQL
NDVTHEMAATTREIKATTSELRDHLADIDDFVRPLRSYFYWEHHCFDIPLCSATRSLFDT
LDGVDTLTDQLRALTDDMNKMEALTPQFLALLPPMITTMKTMRTMMLTMRSTISGVQDQM
ADMQDHATAMGQAFDTAKSGDSFYLPPEAFDNAEFQQGMKLFLSPNGKAVRFVISHESDP
ASTEGIDRIEAIRAATKDAIKATPLQGAKIYIGGTAATYQDIRDGTKYDILIVGIAAVCL
VFIVMLMITQSLIASLVIVGTVLLSLGTAFGLSVLIWQHFVGLQVHWTIVAMSVIVLLAV
GSDYNLLLVSRFKEEVGAGLKTGIIRAMAGTGAVVTSAGLVFAFTMASMAVSELRVIGQV
GTTIGLGLLFDTLVVRSFMTPSIAALLGRWFWWPNMIHSRPTVPEAHTRQGARRIQPHLH
RG