Protein Info for Rv2321c in Mycobacterium tuberculosis H37Rv
Annotation: Probable ornithine aminotransferase (C-terminus part) RocD2 (ornithine--oxo-acid aminotransferase)
These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.
Protein Families and Features
Best Hits
KEGG orthology group: K00819, ornithine--oxo-acid transaminase [EC: 2.6.1.13] (inferred from 100% identity to mbt:JTY_2336)Predicted SEED Role
"Ornithine aminotransferase (EC 2.6.1.13)" in subsystem Arginine and Ornithine Degradation or Dimethylarginine metabolism (EC 2.6.1.13)
MetaCyc Pathways
- L-arginine degradation XIII (reductive Stickland reaction) (5/5 steps found)
- L-ornithine biosynthesis II (3/3 steps found)
- L-proline biosynthesis III (from L-ornithine) (3/3 steps found)
- L-citrulline biosynthesis (6/8 steps found)
- L-arginine degradation VI (arginase 2 pathway) (3/4 steps found)
- L-arginine degradation I (arginase pathway) (2/3 steps found)
- superpathway of L-citrulline metabolism (8/12 steps found)
- L-Nδ-acetylornithine biosynthesis (4/7 steps found)
KEGG Metabolic Maps
Isozymes
Compare fitness of predicted isozymes for: 2.6.1.13
Use Curated BLAST to search for 2.6.1.13
Sequence Analysis Tools
PaperBLAST (search for papers about homologs of this protein)
Search CDD (the Conserved Domains Database, which includes COG and superfam)
Predict protein localization: PSORTb (Gram-negative bacteria)
Predict transmembrane helices and signal peptides: Phobius
Check the current SEED with FIGfam search
Find homologs in fast.genomics or the ENIGMA genome browser
Find the best match in UniProt
Protein Sequence (181 amino acids)
>Rv2321c Probable ornithine aminotransferase (C-terminus part) RocD2 (ornithine--oxo-acid aminotransferase) (Mycobacterium tuberculosis H37Rv) MIADEIQSGLACTGYPFACDHGGVLPDIYLLGKTLGGGAVPLSAMVADREIFGVVHPGEH GSTFGGNPLAAAIGTPVVSMVVWGECQARSAKLGAHLHQRLADLIGDGAVALRGLGWWAD VDIERALAIGTDMSMRLADRGVLLKDTYGAALRFAPPLVITAQEIDCAVRRFADALWEAG S