Protein Info for Rv2274c in Mycobacterium tuberculosis H37Rv
Annotation: Possible toxin MazF8
These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.
Protein Families and Features
No protein families (PFam or TIGRFam), signal peptides, or transmembrane helices were found in this protein.
Best Hits
Swiss-Prot: 100% identical to MAZF8_MYCTU: Putative toxin MazF8 (mazF8) from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
KEGG orthology group: None (inferred from 99% identity to mbb:BCG_2291c)Predicted SEED Role
"MazF8 antibacterial toxin protein"
Sequence Analysis Tools
PaperBLAST (search for papers about homologs of this protein)
Search CDD (the Conserved Domains Database, which includes COG and superfam)
Predict protein localization: PSORTb (Gram-negative bacteria)
Predict transmembrane helices and signal peptides: Phobius
Check the current SEED with FIGfam search
Find homologs in fast.genomics or the ENIGMA genome browser
Find the best match in UniProt
Protein Sequence (105 amino acids)
>Rv2274c Possible toxin MazF8 (Mycobacterium tuberculosis H37Rv) MSIARSAQPIGWISCPPKGGSSCCRCGGGYTHIFCVSAWTGLVVDLQAEQVRSVVTERLR RRIGRGAPILAGTLAPGVGLAAQNREFRQFTGRSAPPSATIAFGE