Protein Info for Rv2252 in Mycobacterium tuberculosis H37Rv

Annotation: Diacylglycerol kinase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 309 PF00781: DAGK_cat" amino acids 13 to 136 (124 residues), 101.6 bits, see alignment E=2.4e-33 TIGR00147: lipid kinase, YegS/Rv2252/BmrU family" amino acids 14 to 306 (293 residues), 135.7 bits, see alignment E=8.1e-44 PF19279: YegS_C" amino acids 149 to 304 (156 residues), 148.3 bits, see alignment E=1.6e-47

Best Hits

Swiss-Prot: 100% identical to DAGK_MYCTU: Diacylglycerol kinase (dagK) from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)

KEGG orthology group: K07029, (no description) (inferred from 100% identity to mtb:TBMG_01728)

Predicted SEED Role

"Diacylglycerol kinase-related protein"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (309 amino acids)

>Rv2252 Diacylglycerol kinase (Mycobacterium tuberculosis H37Rv)
MSAGQLRRHEIGKVTALTNPLSGHGAAVKAAHGAIARLKHRGVDVVEIVGGDAHDARHLL
AAAVAKGTDAVMVTGGDGVVSNALQVLAGTDIPLGIIPAGTGNDHAREFGLPTKNPKAAA
DIVVDGWTETIDLGRIQDDNGIEKWFGTVAATGFDSLVNDRANRMRWPHGRMRYYIAMLA
ELSRLRPLPFRLVLDGTEEIVADLTLADFGNTRSYGGGLLICPNADHSDGLLDITMAQSD
SRTKLLRLFPTIFKGAHVELDEVSTTRAKTVHVECPGINVYADGDFACPLPAEISAVPAA
LQVLRPRHG