Protein Info for Rv2251 in Mycobacterium tuberculosis H37Rv

Annotation: Possible flavoprotein

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 475 signal peptide" amino acids 1 to 34 (34 residues), see Phobius details PF01565: FAD_binding_4" amino acids 50 to 183 (134 residues), 106 bits, see alignment E=1.3e-34 PF02913: FAD-oxidase_C" amino acids 223 to 473 (251 residues), 152.1 bits, see alignment E=2.3e-48

Best Hits

KEGG orthology group: K00803, alkyldihydroxyacetonephosphate synthase [EC: 2.5.1.26] (inferred from 100% identity to mtu:Rv2251)

Predicted SEED Role

"Alkyldihydroxyacetonephosphate synthase (EC 2.5.1.26)" (EC 2.5.1.26)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

Compare fitness of predicted isozymes for: 2.5.1.26

Use Curated BLAST to search for 2.5.1.26

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (475 amino acids)

>Rv2251 Possible flavoprotein (Mycobacterium tuberculosis H37Rv)
MRWRASSAPSISAPPIATGCCTPAASPPQTCCGAKTPVSRMRPTRCCCPAAPTGEDAVAD
ILHYCSDHGIAVVPFGGGTSVVGGLDPVRNDFRAVISLDMRRFDRLHRIDEVSGEAELEA
GVTGPEAERLLGEHGFSLGHFPQSFEFATIGGFAATRSSGQDSAGYGRFNDMILGLRMIT
PVGVLDLGRVPASAAGPDLRQLAIGSEGVFGVITRVRLRVHRIPESTRYEAWSFPDFATG
VAALRTITQTGTGPTVVRLSDEAETGVNLATTEAIGETQITGGCLGITVFEGTQEHTESR
HAETRALLAARGGTSLGEGPARAWERGRFAAPYLRDSLLAAGALCETLETATVWSNTPVL
KAAVTEALTTSLAASGTPALVMCHVSHVYPTGASLYFTVVAGQRGDPIEQWLAAKKAASD
AIMATGGTITHHHAVGSDHRPWMRAEVGDLGVTLLRTIKATLDPAGILNPGKLIP