Protein Info for Rv2154c in Mycobacterium tuberculosis H37Rv

Annotation: FtsW-like protein FtsW

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 524 transmembrane" amino acids 57 to 78 (22 residues), see Phobius details amino acids 90 to 112 (23 residues), see Phobius details amino acids 122 to 142 (21 residues), see Phobius details amino acids 160 to 179 (20 residues), see Phobius details amino acids 191 to 208 (18 residues), see Phobius details amino acids 214 to 231 (18 residues), see Phobius details amino acids 236 to 256 (21 residues), see Phobius details amino acids 312 to 339 (28 residues), see Phobius details amino acids 351 to 375 (25 residues), see Phobius details amino acids 387 to 406 (20 residues), see Phobius details PF01098: FTSW_RODA_SPOVE" amino acids 58 to 412 (355 residues), 428.2 bits, see alignment E=1.2e-132 TIGR02614: cell division protein FtsW" amino acids 59 to 411 (353 residues), 403.8 bits, see alignment E=3.2e-125

Best Hits

Swiss-Prot: 100% identical to FTSW_MYCTU: Probable peptidoglycan glycosyltransferase FtsW (ftsW) from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)

KEGG orthology group: K03588, cell division protein FtsW (inferred from 100% identity to mtc:MT2213)

Predicted SEED Role

"Cell division protein FtsW" in subsystem Bacterial Cell Division or Bacterial Cytoskeleton

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (524 amino acids)

>Rv2154c FtsW-like protein FtsW (Mycobacterium tuberculosis H37Rv)
VLTRLLRRGTSDTDGSQTRGAEPVEGQRTGPEEASNPGSARPRTRFGAWLGRPMTSFHLI
IAVAALLTTLGLIMVLSASAVRSYDDDGSAWVIFGKQVLWTLVGLIGGYVCLRMSVRFMR
RIAFSGFAITIVMLVLVLVPGIGKEANGSRGWFVVAGFSMQPSELAKMAFAIWGAHLLAA
RRMERASLREMLIPLVPAAVVALALIVAQPDLGQTVSMGIILLGLLWYAGLPLRVFLSSL
AAVVVSAAILAVSAGYRSDRVRSWLNPENDPQDSGYQARQAKFALAQGGIFGDGLGQGVA
KWNYLPNAHNDFIFAIIGEELGLVGALGLLGLFGLFAYTGMRIASRSADPFLRLLTATTT
LWVLGQAFINIGYVIGLLPVTGLQLPLISAGGTSTAATLSLIGIIANAARHEPEAVAALR
AGRDDKVNRLLRLPLPEPYLPPRLEAFRDRKRANPQPAQTQPARKTPRTAPGQPARQMGL
PPRPGSPRTADPPVRRSVHHGAGQRYAGQRRTRRVRALEGQRYG