Protein Info for Rv2130c in Mycobacterium tuberculosis H37Rv
Annotation: Cysteine:1D-myo-inosityl 2-amino-2-deoxy--D-glucopyranoside ligase MshC
These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.
Protein Families and Features
Best Hits
Swiss-Prot: 100% identical to MSHC_MYCBP: L-cysteine:1D-myo-inositol 2-amino-2-deoxy-alpha-D-glucopyranoside ligase (mshC) from Mycobacterium bovis (strain BCG / Pasteur 1173P2)
KEGG orthology group: K01883, cysteinyl-tRNA synthetase [EC: 6.1.1.16] (inferred from 100% identity to mbb:BCG_2147c)MetaCyc: 79% identical to L-cysteine : 1 D-myo-inositol 2-amino-2-deoxy-alpha-D-glucopyranoside ligase small subunit (Mycolicibacterium smegmatis)
RXN1G-121 [EC: 6.3.1.13]
Predicted SEED Role
"L-cysteine:1D-myo-inosityl 2-amino-2-deoxy-alpha-D-glucopyranoside ligase MshC" in subsystem Glutathione analogs: mycothiol
MetaCyc Pathways
- tRNA charging (19/21 steps found)
- mycothiol biosynthesis (5/6 steps found)
- thiocoraline biosynthesis (1/7 steps found)
- anguibactin biosynthesis (1/8 steps found)
- pyochelin biosynthesis (1/11 steps found)
- colibactin biosynthesis (6/38 steps found)
KEGG Metabolic Maps
Isozymes
Compare fitness of predicted isozymes for: 6.1.1.16
Use Curated BLAST to search for 6.1.1.16 or 6.3.1.13
Sequence Analysis Tools
PaperBLAST (search for papers about homologs of this protein)
Search CDD (the Conserved Domains Database, which includes COG and superfam)
Compare to protein structures
Predict protein localization: PSORTb (Gram-negative bacteria)
Predict transmembrane helices and signal peptides: Phobius
Check the current SEED with FIGfam search
Find homologs in fast.genomics or the ENIGMA genome browser
Find the best match in UniProt
Protein Sequence (414 amino acids)
>Rv2130c Cysteine:1D-myo-inosityl 2-amino-2-deoxy--D-glucopyranoside ligase MshC (Mycobacterium tuberculosis H37Rv) MQSWYCPPVPVLPGRGPQLRLYDSADRQVRPVAPGSKATMYVCGITPYDATHLGHAATYV TFDLIHRLWLDLGHELHYVQNITDIDDPLFERADRDGVDWRDLAQAEVALFCEDMAALRV LPPQDYVGATEAIAEMVELIEKMLACGAAYVIDREMGEYQDIYFRADATLQFGYESGYDR DTMLRLCEERGGDPRRPGKSDELDALLWRAARPGEPSWPSPFGPGRPGWHVECAAIALSR IGSGLDIQGGGSDLIFPHHEFTAAHAECVSGERRFARHYVHAGMIGWDGHKMSKSRGNLV LVSALRAQDVEPSAVRLGLLAGHYRADRFWSQQVLDEATARLHRWRTATALPAGPAAVDV VARVRRYLADDLDTPKAIAALDGWVTDAVEYGGHDAGAPKLVATAIDALLGVDL