Protein Info for Rv2116 in Mycobacterium tuberculosis H37Rv

Annotation: Conserved lipoprotein LppK

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 189 signal peptide" amino acids 1 to 24 (24 residues), see Phobius details

Best Hits

Swiss-Prot: 100% identical to LPPK_MYCTO: Putative lipoprotein LppK (lppK) from Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)

KEGG orthology group: None (inferred from 100% identity to mbo:Mb2140)

Predicted SEED Role

"Probable conserved lipoprotein lppK"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (189 amino acids)

>Rv2116 Conserved lipoprotein LppK (Mycobacterium tuberculosis H37Rv)
MRRNIRVTLGAATIVAALGLSGCSHPEFKRSSPPAPSLPPVTSSPLEAAPITPLPAPEAL
IDVLSRLADPAVPGTNKVQLIEGATPENAAALDRFTTALRDGSYLPMTFAANDIAWSDNK
PSDVMATVVVTTAHPDNREFTFPMEFVSFKGGWQLSRQTAEMLLAMGNSPDSTPSATSPA
PAPSPTPPG