Protein Info for Rv2101 in Mycobacterium tuberculosis H37Rv

Annotation: Probable helicase HelZ

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 100 200 300 400 500 600 700 800 900 1013 PF12419: DUF3670" amino acids 352 to 486 (135 residues), 142.2 bits, see alignment E=1.2e-45 PF00176: SNF2-rel_dom" amino acids 536 to 819 (284 residues), 228.8 bits, see alignment E=1.2e-71 PF00271: Helicase_C" amino acids 840 to 950 (111 residues), 74.5 bits, see alignment E=1.2e-24

Best Hits

KEGG orthology group: None (inferred from 100% identity to mra:MRA_2115)

Predicted SEED Role

"Helicase, SNF2/RAD54 family"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (1013 amino acids)

>Rv2101 Probable helicase HelZ (Mycobacterium tuberculosis H37Rv)
MLVLHGFWSNSGGMRLWAEDSDLLVKSPSQALRSARPHPFAAPADLIAGIHPGKPATAVL
LLPSLRSAPLDSPELIRLAPRPAARTDPMLLAWTVPVVDLDPTAALAAFDQPAPDVRYGA
SVDYLAELAVFARELVERGRVLPQLRRDTHGAAACWRPVLQGRDVVAMTSLVSAMPPVCR
AEVGGHDPHELATSALDAMVDAAVRAALSPMDLLPPRRGRSKRHRAVEAWLTALTCPDGR
FDAEPDELDALAEALRPWDDVGIGTVGPARATFRLSEVETENEETPAGSLWRLEFLLQST
QDPSLLVPAEQAWNDDGSLRRWLDRPQELLLTELGRASRIFPELVPALRTACPSGLELDA
DGAYRFLSGTAAVLDEAGFGVLLPSWWDRRRKLGLVLSAYTPVDGVVGKASKFGREQLVE
FRWELAVGDDPLSEEEIAALTETKSPLIRLRGQWVALDTEQLRRGLEFLERKPTGRKTTA
EILALAASHPDDVDTPLEVTAVRADGWLGDLLAGAAAASLQPLDPPDGFTATLRPYQQRG
LAWLAFLSSLGLGSCLADDMGLGKTVQLLALETLESVQRHQDRGVGPTLLLCPMSLVGNW
PQEAARFAPNLRVYAHHGGARLHGEALRDHLERTDLVVSTYTTATRDIDELAEYEWNRVV
LDEAQAVKNSLSRAAKAVRRLRAAHRVALTGTPMENRLAELWSIMDFLNPGLLGSSERFR
TRYAIPIERHGHTEPAERLRASTRPYILRRLKTDPAIIDDLPEKIEIKQYCQLTTEQASL
YQAVVADMMEKIENTEGIERRGNVLAAMAKLKQVCNHPAQLLHDRSPVGRRSGKVIRLEE
ILEEILAEGDRVLCFTQFTEFAELLVPHLAARFGRAARDIAYLHGGTPRKRRDEMVARFQ
SGDGPPIFLLSLKAGGTGLNLTAANHVVHLDRWWNPAVENQATDRAFRIGQRRTVQVRKF
ICTGTLEEKIDEMIEEKKALADLVVTDGEGWLTELSTRDLREVFALSEGAVGE