Protein Info for Rv2098c in Mycobacterium tuberculosis H37Rv

Annotation: PE-PGRS family protein PE_PGRS36

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 434 PF00934: PE" amino acids 1 to 36 (36 residues), 41.6 bits, see alignment 1.3e-14 PF21526: PGRS" amino acids 58 to 129 (72 residues), 60.5 bits, see alignment E=1.6e-20

Best Hits

Swiss-Prot: 100% identical to PG36_MYCBO: Uncharacterized PE-PGRS family protein PE_PGRS36 (PE_PGRS36) from Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97)

KEGG orthology group: None (inferred from 100% identity to mbt:JTY_2112)

Predicted SEED Role

"FIG033545: PE-PGRS family protein" in subsystem Cluster-based Subsystem Grouping Hypotheticals - perhaps Proteosome Related

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (434 amino acids)

>Rv2098c PE-PGRS family protein PE_PGRS36 (Mycobacterium tuberculosis H37Rv)
GQSYQAVSAQAAAFHDRFVQLLNAGGGSYASAEIANAQQNLLNAVNAPTQTLLGRPLVGD
GADGASGPVGQPGGDGGILWGNGGNGGDSTSPGVAGGAGGSAGLIGNGGRGGNGAPGGAG
GNGGLGGLLLGNGGAGGVGGTGDNGVGDLGAGGGGGDGGLGGRAGLIGHGGAGGNGGDGG
HGGSGKAGGSGGSGGFGQFGGAGGLLYGNGGAAGSGGNGGDAGTGVSSDGFAGLGGSGGR
GGDAGLIGVGGGGGGNGGDPGLGARLFQVGSRGGDGGVGGWLYGDGGGGGDGGNGGLPFI
GSTNAGNGGSARLIGNGGAGGSGGSGAPGSVSSGGVGGAGNPGGSGGNGGVWYGNGGAGG
AAGQGGPGMNTTSPGGPGGVGGHGGTAILFGDGGAGGAGAAGGPGTPDGAAGPGGSGGTG
GLLFGVPGPSGPDG