Protein Info for Rv2095c in Mycobacterium tuberculosis H37Rv

Annotation: Proteasome accessory factor C PafC

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 316 PF19187: HTH_PafC" amino acids 6 to 119 (114 residues), 141.3 bits, see alignment E=1.8e-45 PF13280: WYL" amino acids 140 to 204 (65 residues), 64.8 bits, see alignment E=9e-22 PF25583: WCX" amino acids 235 to 307 (73 residues), 68.6 bits, see alignment E=7.3e-23

Best Hits

Swiss-Prot: 100% identical to PAFC_MYCTU: Protein PafC (pafC) from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)

KEGG orthology group: K13573, proteasome accessory factor C (inferred from 100% identity to mbo:Mb2122c)

Predicted SEED Role

"FIG019733: possible DNA-binding protein" in subsystem Cluster-based Subsystem Grouping Hypotheticals - perhaps Proteosome Related

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (316 amino acids)

>Rv2095c Proteasome accessory factor C PafC (Mycobacterium tuberculosis H37Rv)
MSALSTRLVRLLNMVPYFQANPRITRAEAAAELGVTAKQLEEDLNQLWMCGLPGYSPGDL
IDFEFCGDTIEVTFSAGIDRPLKLTSPEATGLLVALRALADIPGVVDPQAARSAIAKIAA
AAGAVAAVAEQAPTESPAAAAVRAAVRNSRALTIDYYAASHDTLTTRIVDPIRVLLIGGH
SYLEAWSREAEGVRLFRFDRIVDAAELGEPAVPPESARQAPPDTSLFDGDLSLPSATLRV
APSASWMLEYYPIRELRQLPDGSCEVAMTYASEDWMTRLLLGFGSDVRVLAPESLAQRVR
DAATAALDAYQAAAPP