Protein Info for Rv2089c in Mycobacterium tuberculosis H37Rv

Annotation: Dipeptidase PepE

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 375 signal peptide" amino acids 1 to 29 (29 residues), see Phobius details PF01321: Creatinase_N" amino acids 14 to 146 (133 residues), 30.9 bits, see alignment E=3.5e-11 PF00557: Peptidase_M24" amino acids 154 to 356 (203 residues), 225.6 bits, see alignment E=5.8e-71

Best Hits

Swiss-Prot: 100% identical to PEPE_MYCTO: Probable dipeptidase PepE (pepE) from Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)

KEGG orthology group: K01274, D-alanyl-D-alanine dipeptidase [EC: 3.4.13.-] (inferred from 100% identity to mbt:JTY_2103)

Predicted SEED Role

"Probable dipeptidase PepE (EC 3.4.13.-)" (EC 3.4.13.-)

Isozymes

No predicted isozymes

Use Curated BLAST to search for 3.4.13.-

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (375 amino acids)

>Rv2089c Dipeptidase PepE (Mycobacterium tuberculosis H37Rv)
MGSRRFDAEVYARRLALAAAATADAGLAGLVITPGYDLCYLIGSRAETFERLTALVLPAA
GAPAVVLPRLELAALKQSAAAELGLRVCDWVDGDDPYGLVSAVLGGAPVATAVTDSMPAL
HMLPLADALGVLPVLATDVLRRLRMVKEETEIDALRKAGAAIDRVHARVPEFLVPGRTEA
DVAADIAEAIVAEGHSEVAFVIVGSGPHGADPHHGYSDRELREGDIVVVDIGGTYGPGYH
SDSTRTYSIGEPDSDVAQSYSMLQRAQRAAFEAIRPGVTAEQVDAAARDVLAEAGLAEYF
VHRTGHGIGLCVHEEPYIVAGNDLVLVPGMAFSIEPGIYFPGRWGARIEDIVIVTEDGAV
SVNNCPHELIVVPVS