Protein Info for Rv2073c in Mycobacterium tuberculosis H37Rv

Annotation: Probable shortchain dehydrogenase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 249 transmembrane" amino acids 223 to 243 (21 residues), see Phobius details PF00106: adh_short" amino acids 9 to 195 (187 residues), 89 bits, see alignment E=4.4e-29 PF08659: KR" amino acids 9 to 170 (162 residues), 37.8 bits, see alignment E=2.8e-13 PF13561: adh_short_C2" amino acids 17 to 197 (181 residues), 58.7 bits, see alignment E=1e-19

Best Hits

Swiss-Prot: 100% identical to Y2073_MYCTU: Uncharacterized oxidoreductase Rv2073c (Rv2073c) from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)

KEGG orthology group: K00540, [EC: 1.-.-.-] (inferred from 99% identity to mtc:MT2133)

MetaCyc: 42% identical to decaprenylphospho-beta-D-erythro-pentofuranosid-2-ulose 2-reductase (Mycolicibacterium smegmatis MC2 155)
RXN-11081 [EC: 1.1.1.333]

Predicted SEED Role

"Short-chain dehydrogenase/reductase SDR"

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

Compare fitness of predicted isozymes for: 1.-.-.-

Use Curated BLAST to search for 1.-.-.- or 1.1.1.333

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (249 amino acids)

>Rv2073c Probable shortchain dehydrogenase (Mycobacterium tuberculosis H37Rv)
VDDTGAAPVVIFGGRSQIGGELARRLAAGATMVLAARNADQLADQAAALRAAGAIAVHTR
EFDADDLAAHGPLVASLVAEHGPIGTAVLAFGILGDQARAETDAAHAVAIVHTDYVAQVS
LLTHLAAAMRTAGRGSLVVFSSVAGIRVRRANYVYGSAKAGLDGFASGLADALHGTGVRL
LIARPGFVIGRMTEGMTPAPLSVTPERVAAATARALVNGKRVVWIPWALRPMFVALRLLP
RFVWRRMPR