Protein Info for Rv2060 in Mycobacterium tuberculosis H37Rv

Annotation: Possible conserved integral membrane protein

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 133 signal peptide" amino acids 1 to 24 (24 residues), see Phobius details transmembrane" amino acids 39 to 68 (30 residues), see Phobius details amino acids 78 to 103 (26 residues), see Phobius details amino acids 109 to 129 (21 residues), see Phobius details PF00950: ABC-3" amino acids 3 to 127 (125 residues), 64.9 bits, see alignment E=4.3e-22

Best Hits

KEGG orthology group: K02075, zinc/manganese transport system permease protein (inferred from 100% identity to mbo:Mb2086)

Predicted SEED Role

"ABC-type Mn2+ and Zn2+ transport systems, permease components"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (133 amino acids)

>Rv2060 Possible conserved integral membrane protein (Mycobacterium tuberculosis H37Rv)
MLTVVCLLVVTVLAICYRPLLFATVDPEVAAARGVPVRALGIVFAALMGVVAAQAVQIVG
ALLVMSLLITPAAAAARVVVAPVAAIATSVVFAEVSAVGGILLSLAPGVPVSVFVATISF
VIYLICWLLRRRR