Protein Info for Rv2031c in Mycobacterium tuberculosis H37Rv

Annotation: Heat shock protein HspX (alpha-crystallin homolog) (14 kDa antigen) (HSP16.3)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 144 PF00011: HSP20" amino acids 45 to 140 (96 residues), 86.4 bits, see alignment E=1.3e-28 PF17886: ArsA_HSP20" amino acids 48 to 125 (78 residues), 28.1 bits, see alignment E=1.2e-10

Best Hits

Swiss-Prot: 100% identical to 14KD_MYCBO: 14 kDa antigen (hspX) from Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97)

KEGG orthology group: None (inferred from 100% identity to mtf:TBFG_12068)

Predicted SEED Role

"14 kDa antigen (16 kDa antigen) (HSP 16.3)"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (144 amino acids)

>Rv2031c Heat shock protein HspX (alpha-crystallin homolog) (14 kDa antigen) (HSP16.3) (Mycobacterium tuberculosis H37Rv)
MATTLPVQRHPRSLFPEFSELFAAFPSFAGLRPTFDTRLMRLEDEMKEGRYEVRAELPGV
DPDKDVDIMVRDGQLTIKAERTEQKDFDGRSEFAYGSFVRTVSLPVGADEDDIKATYDKG
ILTVSVAVSEGKPTEKHIQIRSTN