Protein Info for Rv1994c in Mycobacterium tuberculosis H37Rv

Annotation: Metal sensor transcriptional regulator CmtR (ArsR-SmtB family)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 118 PF12840: HTH_20" amino acids 18 to 64 (47 residues), 35.8 bits, see alignment E=9e-13 PF01022: HTH_5" amino acids 20 to 64 (45 residues), 60.3 bits, see alignment E=2e-20

Best Hits

Swiss-Prot: 100% identical to CMTR_MYCBO: HTH-type transcriptional regulator CmtR (cmtR) from Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97)

KEGG orthology group: None (inferred from 100% identity to mtc:MT2050)

Predicted SEED Role

"Transcriptional regulator, ArsR family"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (118 amino acids)

>Rv1994c Metal sensor transcriptional regulator CmtR (ArsR-SmtB family) (Mycobacterium tuberculosis H37Rv)
MLTCEMRESALARLGRALADPTRCRILVALLDGVCYPGQLAAHLGLTRSNVSNHLSCLRG
CGLVVATYEGRQVRYALADSHLARALGELVQVVLAVDTDQPCVAERAASGEAVEMTGS