Protein Info for Rv1932 in Mycobacterium tuberculosis H37Rv

Annotation: Probable thiol peroxidase Tpx

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF00578: AhpC-TSA
  • amino acids 20 to 143 (124 residues), 60.8 bits, E=1.3e-20
• PF08534: Redoxin
  • amino acids 20 to 160 (141 residues), 108.1 bits, E=3.6e-35

Best Hits

Swiss-Prot: 100% identical to TPX_MYCTO: Thiol peroxidase (tpx) from Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)

KEGG orthology group: K11065, thiol peroxidase, atypical 2-Cys peroxiredoxin [EC: 1.11.1.15] (inferred from 100% identity to mbt:JTY_1955)

MetaCyc: 53% identical to lipid hydroperoxide peroxidase (Escherichia coli K-12 substr. MG1655)
1.11.1.15-RXN [EC: 1.11.1.24]

Predicted SEED Role

"Thiol peroxidase, Tpx-type (EC 1.11.1.15)" in subsystem Thioredoxin-disulfide reductase (EC 1.11.1.15)

KEGG Metabolic Maps

• Glutathione metabolism

Isozymes

Compare fitness of predicted isozymes for: 1.11.1.15

Use Curated BLAST to search for 1.11.1.15 or 1.11.1.24

Protein Sequence (165 amino acids)

>Rv1932 Probable thiol peroxidase Tpx (Mycobacterium tuberculosis H37Rv)
MAQITLRGNAINTVGELPAVGSPAPAFTLTGGDLGVISSDQFRGKSVLLNIFPSVDTPVC
ATSVRTFDERAAASGATVLCVSKDLPFAQKRFCGAEGTENVMPASAFRDSFGEDYGVTIA
DGPMAGLLARAIVVIGADGNVAYTELVPEIAQEPNYEAALAALGA