Protein Info for Rv1886c in Mycobacterium tuberculosis H37Rv

Annotation: Secreted antigen 85-B FbpB (85B) (antigen 85 complex B) (mycolyl transferase 85B) (fibronectin-binding protein B) (extracellular alpha-antigen)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

Best Hits

Swiss-Prot: 100% identical to A85B_MYCTU: Diacylglycerol acyltransferase/mycolyltransferase Ag85B (fbpB) from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)

KEGG orthology group: None (inferred from 100% identity to mbb:BCG_1923c)

MetaCyc: 100% identical to antigen 85B (Mycobacterium tuberculosis H37Rv)
Trehalose O-mycolyltransferase. [EC: 2.3.1.122]; 2.3.1.- [EC: 2.3.1.122]; 2.3.1.- [EC: 2.3.1.122]; 2.3.1.- [EC: 2.3.1.122]; 2.3.1.- [EC: 2.3.1.122]; 2.3.1.- [EC: 2.3.1.122]; 2.3.1.- [EC: 2.3.1.122]; 2.3.1.- [EC: 2.3.1.122]; 2.3.1.- [EC: 2.3.1.122]; 2.3.1.- [EC: 2.3.1.122]

Predicted SEED Role

"Esterase, secreted fibronectin-binding protein antigen 85-B FbpB"

MetaCyc Pathways

mycolate biosynthesis (165/205 steps found)
superpathway of mycolyl-arabinogalactan-peptidoglycan complex biosynthesis (33/33 steps found)
mycolyl-arabinogalactan-peptidoglycan complex biosynthesis (18/18 steps found)
superpathway of mycolate biosynthesis (166/239 steps found)

Isozymes

No predicted isozymes

Use Curated BLAST to search for 2.3.1.122

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (325 amino acids)

>Rv1886c Secreted antigen 85-B FbpB (85B) (antigen 85 complex B) (mycolyl transferase 85B) (fibronectin-binding protein B) (extracellular alpha-antigen) (Mycobacterium tuberculosis H37Rv)
MTDVSRKIRAWGRRLMIGTAAAVVLPGLVGLAGGAATAGAFSRPGLPVEYLQVPSPSMGR
DIKVQFQSGGNNSPAVYLLDGLRAQDDYNGWDINTPAFEWYYQSGLSIVMPVGGQSSFYS
DWYSPACGKAGCQTYKWETFLTSELPQWLSANRAVKPTGSAAIGLSMAGSSAMILAAYHP
QQFIYAGSLSALLDPSQGMGPSLIGLAMGDAGGYKAADMWGPSSDPAWERNDPTQQIPKL
VANNTRLWVYCGNGTPNELGGANIPAEFLENFVRSSNLKFQDAYNAAGGHNAVFNFPPNG
THSWEYWGAQLNAMKGDLQSSLGAG