Protein Info for Rv1858 in Mycobacterium tuberculosis H37Rv

Annotation: Probable molybdenum-transport integral membrane protein ABC transporter ModB

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 264 transmembrane" amino acids 12 to 31 (20 residues), see Phobius details amino acids 53 to 77 (25 residues), see Phobius details amino acids 89 to 110 (22 residues), see Phobius details amino acids 122 to 147 (26 residues), see Phobius details amino acids 176 to 197 (22 residues), see Phobius details amino acids 234 to 255 (22 residues), see Phobius details TIGR01581: NifC-like ABC-type porter" amino acids 30 to 250 (221 residues), 293.8 bits, see alignment E=8e-92 TIGR02141: molybdate ABC transporter, permease protein" amino acids 53 to 254 (202 residues), 224.1 bits, see alignment E=1.5e-70 PF00528: BPD_transp_1" amino acids 69 to 250 (182 residues), 56.5 bits, see alignment E=1.6e-19

Best Hits

Swiss-Prot: 100% identical to MODB_MYCBO: Molybdenum transport system permease protein ModB (modB) from Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97)

KEGG orthology group: K02018, molybdate transport system permease protein (inferred from 100% identity to mtf:TBFG_11886)

Predicted SEED Role

"Molybdenum transport system permease protein ModB (TC 3.A.1.8.1)" in subsystem Molybdenum cofactor biosynthesis or Transport of Molybdenum (TC 3.A.1.8.1)

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (264 amino acids)

>Rv1858 Probable molybdenum-transport integral membrane protein ABC transporter ModB (Mycobacterium tuberculosis H37Rv)
MHPPTDLPRWVYLPAIAGIVFVAMPLVAIAIRVDWPRFWALITTPSSQTALLLSVKTAAA
STVLCVLLGVPMALVLARSRGRLVRSLRPLILLPLVLPPVVGGIALLYAFGRLGLIGRYL
EAAGISIAFSTAAVVLAQTFVSLPYLVISLEGAARTAGADYEVVAATLGARPGTVWWRVT
LPLLLPGVVSGSVLAFARSLGEFGATLTFAGSRQGVTRTLPLEIYLQRVTDPDAAVALSL
LLVVVAALVVLGVGARTPIGTDTR