Protein Info for Rv1845c in Mycobacterium tuberculosis H37Rv

Annotation: Possible sensor-transducer protein BlaR

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 316 signal peptide" amino acids 1 to 22 (22 residues), see Phobius details transmembrane" amino acids 37 to 61 (25 residues), see Phobius details amino acids 70 to 111 (42 residues), see Phobius details amino acids 281 to 307 (27 residues), see Phobius details PF01435: Peptidase_M48" amino acids 151 to 201 (51 residues), 33 bits, see alignment 2.7e-12

Best Hits

KEGG orthology group: None (inferred from 99% identity to mbb:BCG_1881c)

Predicted SEED Role

"Peptidase M48, Ste24p precursor"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (316 amino acids)

>Rv1845c Possible sensor-transducer protein BlaR (Mycobacterium tuberculosis H37Rv)
VSALAFTILAVLLAGPTPALLARATWPLRAPRAAMVLWQAIALAAVLSSFSAGIAIASRL
LMPGPDGRPTTSFVGAAGRLGWPLWAAYITVFALTVLVGARLAVAVVRVATATRRRRAHH
RMVVDLVGVGHNGALAQPCARARDLRVLDVAQPLAYCLPGVRSRVVVSEGTLTALADAEV
AAILTHERAHLRARHDLVLEAFTAVHAAFPRLVRSANALGAVQLLVELLADDAAVRAAGR
TPLARALVACASGRAPSGALAVGGPSTVLRVRRLSGRGNSAVLSAAAYLAAAAVLVVPTV
ALAVPWLTQLQRLFIA