Protein Info for Rv1790 in Mycobacterium tuberculosis H37Rv

Annotation: PPE family protein PPE27

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 transmembrane" amino acids 57 to 75 (19 residues), see Phobius details PF00823: PPE" amino acids 2 to 164 (163 residues), 223 bits, see alignment E=2.3e-70 PF12484: PPE-SVP" amino acids 267 to 345 (79 residues), 66.7 bits, see alignment E=2.8e-22

Best Hits

Swiss-Prot: 88% identical to PPE25_MYCTU: Uncharacterized PPE family protein PPE25 (PPE25) from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)

KEGG orthology group: None (inferred from 100% identity to mbo:Mb1818)

Predicted SEED Role

"PPE family protein"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (350 amino acids)

>Rv1790 PPE family protein PPE27 (Mycobacterium tuberculosis H37Rv)
MDFGALPPEINSGRMYCGPGSGPMLAAAAAWDGVAVELGLAATGYASVIAELTGAPWVGA
ASLSMVAAATPYVAWLSQAAARAEQAGMQAAAAAAAYEAAFVMTVPPPVITANRVLVMTL
IATNFFGQNSAAIAVAEAQYAEMWAQDAVAMYGYAAASASASRLIPFAAPPKTTNSAGVV
AQAVASVSWPNPNDWWLVRLLGSITPTERTTIVRLLGQSYLATGMARFLTSIAQQLTFGP
GGTTAGSGGAWYPTPQFAGLGAGPAVSASLARAEPVGRLSVPPSWAVAAPAFAEKPEAGT
PMSVIGEASSCGQGGLLRGIPLARAGRRTGAFAHRYGFRHSVITRSPSAG