Protein Info for Rv1743 in Mycobacterium tuberculosis H37Rv

Annotation: Probable transmembrane serine/threonine-protein kinase E PknE (protein kinase E) (STPK E)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 566 transmembrane" amino acids 337 to 359 (23 residues), see Phobius details PF00069: Pkinase" amino acids 16 to 229 (214 residues), 147.3 bits, see alignment E=1.1e-46 PF07714: PK_Tyr_Ser-Thr" amino acids 18 to 260 (243 residues), 95.6 bits, see alignment E=6.3e-31 PF06293: Kdo" amino acids 95 to 159 (65 residues), 22.4 bits, see alignment E=1.5e-08 PF13462: Thioredoxin_4" amino acids 389 to 565 (177 residues), 34.1 bits, see alignment E=6e-12

Best Hits

Swiss-Prot: 100% identical to PKNE_MYCTO: Serine/threonine-protein kinase PknE (pknE) from Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)

KEGG orthology group: K08884, serine/threonine protein kinase, bacterial [EC: 2.7.11.1] (inferred from 100% identity to mtu:Rv1743)

Predicted SEED Role

"Serine/threonine-protein kinase PknE (EC 2.7.11.1)" (EC 2.7.11.1)

KEGG Metabolic Maps

Isozymes

Compare fitness of predicted isozymes for: 2.7.11.1

Use Curated BLAST to search for 2.7.11.1

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (566 amino acids)

>Rv1743 Probable transmembrane serine/threonine-protein kinase E PknE (protein kinase E) (STPK E) (Mycobacterium tuberculosis H37Rv)
MDGTAESREGTQFGPYRLRRLVGRGGMGDVYEAEDTVRERIVALKLMSETLSSDPVFRTR
MQREARTAGRLQEPHVVPIHDFGEIDGQLYVDMRLINGVDLAAMLRRQGPLAPPRAVAIV
RQIGSALDAAHAAGATHRDVKPENILVSADDFAYLVDFGIASATTDEKLTQLGNTVGTLY
YMAPERFSESHATYRADIYALTCVLYECLTGSPPYQGDQLSVMGAHINQAIPRPSTVRPG
IPVAFDAVIARGMAKNPEDRYVTCGDLSAAAHAALATADQDRATDILRRSQVAKLPVPST
HPVSPGTRWPQPTPWAGGAPPWGPPSSPLPRSARQPWLWVGVAVAVVVALAGGLGIALAH
PWRSSGPRTSAPPPPPPADAVELRVLNDGVFVGSSVAPTTIDIFNEPICPPCGSFIRSYA
SDIDTAVADKQLAVRYHLLNFLDDQSHSKNYSTRAVAASYCVAGQNDPKLYASFYSALFG
SDFQPQENAASDRTDAELAHLAQTVGAEPTAISCIKSGADLGTAQTKATNASETLAGFNA
SGTPFVWDGSMVVNYQDPSWLARLIG