Protein Info for Rv1719 in Mycobacterium tuberculosis H37Rv

Annotation: Probable transcriptional regulatory protein

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 259 PF09339: HTH_IclR" amino acids 16 to 64 (49 residues), 50.8 bits, see alignment 4e-17 PF12802: MarR_2" amino acids 19 to 65 (47 residues), 44.5 bits, see alignment 4.8e-15 PF01047: MarR" amino acids 21 to 64 (44 residues), 32.1 bits, see alignment 3e-11 PF13384: HTH_23" amino acids 22 to 62 (41 residues), 26.9 bits, see alignment 1.2e-09 PF13412: HTH_24" amino acids 22 to 62 (41 residues), 41.5 bits, see alignment 2.8e-14 PF13545: HTH_Crp_2" amino acids 32 to 68 (37 residues), 36.5 bits, see alignment 1.4e-12 PF01614: IclR" amino acids 127 to 253 (127 residues), 117.5 bits, see alignment E=1.3e-37

Best Hits

Swiss-Prot: 43% identical to TTGV_PSEPT: HTH-type transcriptional regulator TtgV (ttgV) from Pseudomonas putida (strain DOT-T1E)

KEGG orthology group: None (inferred from 100% identity to mtf:TBFG_11734)

Predicted SEED Role

"Transcriptional regulator, IclR family" in subsystem Homogentisate pathway of aromatic compound degradation

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (259 amino acids)

>Rv1719 Probable transcriptional regulatory protein (Mycobacterium tuberculosis H37Rv)
VSAEEQDTRSGGIQVIARAAELLRVLQAHPGGLSQAEIGERVGMARSTVSRILNALEDEG
LVASRGARGPYRLGPEITRMATTVRLGVVTEMHPFLTELSRELDETVDLSILDGDRADVV
DQVVPPQRLRAVSAVGESFPLYCCANGKALLAALPPERQARALPSRLAPLTANTITDRAA
LRDELNRIRVDGVAYDREEQTEGICAVGAVLRGVSVELVAVSVPVPAQRFYGREAELAGA
LLAWVSKVDAWFNGTEDRK