Protein Info for Rv1707 in Mycobacterium tuberculosis H37Rv

Annotation: Probable conserved transmembrane protein

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 486 transmembrane" amino acids 12 to 30 (19 residues), see Phobius details amino acids 37 to 57 (21 residues), see Phobius details amino acids 83 to 101 (19 residues), see Phobius details amino acids 111 to 131 (21 residues), see Phobius details amino acids 137 to 155 (19 residues), see Phobius details amino acids 162 to 179 (18 residues), see Phobius details amino acids 216 to 240 (25 residues), see Phobius details amino acids 260 to 279 (20 residues), see Phobius details amino acids 290 to 311 (22 residues), see Phobius details amino acids 317 to 336 (20 residues), see Phobius details amino acids 349 to 377 (29 residues), see Phobius details PF00916: Sulfate_transp" amino acids 7 to 133 (127 residues), 95.3 bits, see alignment E=3.5e-31 amino acids 143 to 353 (211 residues), 142.5 bits, see alignment E=1.6e-45 PF01740: STAS" amino acids 388 to 469 (82 residues), 45.8 bits, see alignment E=4.4e-16

Best Hits

KEGG orthology group: K03321, sulfate permease, SulP family (inferred from 99% identity to mbt:JTY_1721)

Predicted SEED Role

"Sulfate permease" in subsystem Cysteine Biosynthesis

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (486 amino acids)

>Rv1707 Probable conserved transmembrane protein (Mycobacterium tuberculosis H37Rv)
VLQRIARELLSGVAVAIVALPLAIAFGITATGTSQGALIGLYGAIFAGFFAAVFGGTPGQ
VTGPTGPITVVATATIAEHGLEGAFFAFILAGVFQILFGACRLGSLIRYVPHPVISGFMG
GIAILIIMTQLDQVRSSSLLVLVTVVLLLASGRFIKAIPPSLLVLVLVSSVLPLAAPWLR
DLRAGPVSINRTVDYIGEIPQAMPSFDFPQVANSTMLQVLLSAVAIALLGSLDSLLTSLV
MDNIRGTRHRSNKELIGQGIGNIAAGLFGGLSGAGATVRSVVNVRNGGQTALSAATHSVV
LFVFVAGLGAVVQYIPLAVLSGILILVAVGMFDWHAMRKAHVSPRGDVIVMFTTMIITVV
VDLTIAVMVGIALSLLVHRLRSRQRKAKVTQDDTGTYRIDGPLSFLSVDGVFGSLRDGRE
DVSLDLQHVTYLDTSGARALLYFIDHSEKDGVAVSIKRIPPRLESQLTALADNEQRDKLR
TVLESA