Protein Info for Rv1694 in Mycobacterium tuberculosis H37Rv

Annotation: 2'-O-methyltransferase TlyA

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• TIGR00478: TlyA family rRNA methyltransferase/putative hemolysin
  • amino acids 6 to 238 (233 residues), 206.7 bits, E=1.6e-65
• PF01479: S4
  • amino acids 6 to 46 (41 residues), 30.3 bits, 2.8e-11
• PF01728: FtsJ
  • amino acids 62 to 244 (183 residues), 155.2 bits, E=1.9e-49

Best Hits

Swiss-Prot: 100% identical to TLYA_MYCTU: 16S/23S rRNA (cytidine-2'-O)-methyltransferase TlyA (tlyA) from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)

KEGG orthology group: K06442, putative hemolysin (inferred from 100% identity to mbo:Mb1720)

MetaCyc: 100% identical to 16S rRNA (cytidine1409-2'-O)-methyltransferase [multifunctional] (Mycobacterium tuberculosis H37Rv)
RXN-12462 [EC: 2.1.1.227]; RXN-12463 [EC: 2.1.1.227, 2.1.1.226]

Predicted SEED Role

"RNA binding methyltransferase FtsJ like"

Isozymes

No predicted isozymes

Use Curated BLAST to search for 2.1.1.226 or 2.1.1.227

Protein Sequence (268 amino acids)

>Rv1694 2'-O-methyltransferase TlyA (Mycobacterium tuberculosis H37Rv)
VARRARVDAELVRRGLARSRQQAAELIGAGKVRIDGLPAVKPATAVSDTTALTVVTDSER
AWVSRGAHKLVGALEAFAIAVAGRRCLDAGASTGGFTEVLLDRGAAHVVAADVGYGQLAW
SLRNDPRVVVLERTNARGLTPEAIGGRVDLVVADLSFISLATVLPALVGCASRDADIVPL
VKPQFEVGKGQVGPGGVVHDPQLRARSVLAVARRAQELGWHSVGVKASPLPGPSGNVEYF
LWLRTQTDRALSAKGLEDAVHRAISEGP