Protein Info for Rv1663 in Mycobacterium tuberculosis H37Rv

Annotation: Probable polyketide synthase Pks17

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 502 PF13602: ADH_zinc_N_2" amino acids 8 to 55 (48 residues), 27.5 bits, see alignment 2.4e-09 PF08659: KR" amino acids 64 to 239 (176 residues), 198.3 bits, see alignment E=4.9e-62 PF00106: adh_short" amino acids 65 to 220 (156 residues), 46.4 bits, see alignment E=1.5e-15 PF02719: Polysacc_synt_2" amino acids 66 to 196 (131 residues), 30.5 bits, see alignment E=1e-10 PF01370: Epimerase" amino acids 66 to 206 (141 residues), 49.5 bits, see alignment E=1.8e-16 PF01073: 3Beta_HSD" amino acids 67 to 201 (135 residues), 24.3 bits, see alignment E=6.7e-09 PF16363: GDP_Man_Dehyd" amino acids 67 to 151 (85 residues), 28 bits, see alignment E=6.9e-10 PF13561: adh_short_C2" amino acids 76 to 222 (147 residues), 34.6 bits, see alignment E=7.2e-12 PF00550: PP-binding" amino acids 350 to 410 (61 residues), 55.4 bits, see alignment E=2.7e-18

Best Hits

KEGG orthology group: K12439, polyketide synthase 17 (inferred from 100% identity to mtf:TBFG_11681)

MetaCyc: 100% identical to Pks17 (Mycobacterium tuberculosis H37Rv)
2.3.1.M8 [EC: 2.3.1.M8]

Predicted SEED Role

"Polyketide synthase"

Isozymes

No predicted isozymes

Use Curated BLAST to search for 2.3.1.M8

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (502 amino acids)

>Rv1663 Probable polyketide synthase Pks17 (Mycobacterium tuberculosis H37Rv)
MEAGPQRIAQMLAELVELFKTEALHRLPVKSWDVRHAREAYRFLSQARHVGKVVLTMPDA
WAAGTVLITGGTGMAGSAVARHLVSRYGVRQVVLASRAGEHTESVAALVDELGSAGARVQ
VVSCDVADRDAVAGLVASQPDLTAVFHAAGVLDDAVITGLTPERVDKVLRAKVDGAWNLH
ELTRHLDVSAFVLFSSMAGIVGAPGQANYAAANAFLDGLAAYRRSRGLAALSVAWGLWEQ
ASAMTEHLGERDRVRMSRVGLAPLPTNQAMGFLDAALLADRPVVVAARLDRAALAGAELP
ALFSQLVAGPIRRIIDGADEVSGSGLASRLHGLTPEQRHRELTELVCSNAAIVLGHSGTE
IDAHKAFQDLGFDSLTAVELRNRLKTATGLTLPPTLIFDYPTAAELAEHLDIQLANAPAV
TVDQPNPSTRFNEVTRELQALLDQPNWNPDDKTRLIKRLQAILTDCTAPPASSGPSTTHD
DEDITTATESQLFAILDDELGP