Protein Info for Rv1662 in Mycobacterium tuberculosis H37Rv

Annotation: Probable polyketide synthase Pks8

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 100 200 300 400 500 600 700 800 900 1000 1100 1200 1300 1400 1500 1602 transmembrane" amino acids 949 to 971 (23 residues), see Phobius details amino acids 1452 to 1471 (20 residues), see Phobius details amino acids 1483 to 1504 (22 residues), see Phobius details PF08990: Docking" amino acids 7 to 30 (24 residues), 29.8 bits, see alignment (E = 2.7e-10) PF00109: ketoacyl-synt" amino acids 34 to 281 (248 residues), 321.4 bits, see alignment E=3.2e-99 PF00108: Thiolase_N" amino acids 188 to 235 (48 residues), 28.9 bits, see alignment (E = 5.2e-10) PF02801: Ketoacyl-synt_C" amino acids 289 to 404 (116 residues), 143.9 bits, see alignment 1.6e-45 PF16197: KAsynt_C_assoc" amino acids 407 to 526 (120 residues), 47.7 bits, see alignment 1.3e-15 PF22621: CurL-like_PKS_C" amino acids 477 to 534 (58 residues), 37.6 bits, see alignment (E = 1.2e-12) PF22336: RhiE-like_linker" amino acids 477 to 543 (67 residues), 30.1 bits, see alignment (E = 2.7e-10) PF00698: Acyl_transf_1" amino acids 561 to 872 (312 residues), 213.5 bits, see alignment E=3.7e-66 PF21089: PKS_DH_N" amino acids 921 to 1020 (100 residues), 87.8 bits, see alignment 3e-28 PF14765: PS-DH" amino acids 1044 to 1189 (146 residues), 88.3 bits, see alignment E=3e-28 PF22953: SpnB_Rossmann" amino acids 1243 to 1328 (86 residues), 46.5 bits, see alignment 3.4e-15 PF08240: ADH_N" amino acids 1373 to 1449 (77 residues), 39 bits, see alignment 5.7e-13 PF00107: ADH_zinc_N" amino acids 1491 to 1583 (93 residues), 41.9 bits, see alignment 6.4e-14 PF13602: ADH_zinc_N_2" amino acids 1527 to 1582 (56 residues), 30.4 bits, see alignment (E = 4.9e-10)

Best Hits

MetaCyc: 100% identical to Pks8 (Mycobacterium tuberculosis H37Rv)
2.3.1.M8 [EC: 2.3.1.M8]

Predicted SEED Role

"Probable polyketide synthase pks7"

Isozymes

No predicted isozymes

Use Curated BLAST to search for 2.3.1.M8

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (1602 amino acids)

>Rv1662 Probable polyketide synthase Pks8 (Mycobacterium tuberculosis H37Rv)
MSGTTTHVDYLKRLTADLRRTRRRLSDLEAKLSEPVAVVGMGCRYPGGVDSPETLWELVA
QGRDAVSDFPADRGWDVDGLFDPDPDACGKMYTRRGTFLEHAGDFDAGFFGIGPSEALAM
DPQQRLLLEVSWEALERTGIDPTKLRGSATGVFAGVIHAGYGGQLSGELEGYGLTGSTLS
VASGRVAYVLGLEGPAVSVDTACSSSLVALHLAVQSLRSGECDLALAGGVTVMATPAAFV
EFSRQRALARDGRCKVYAGAADGTAWSEGAGVLVVERLVDARRLGHPVLALVRGSAVNQD
GASNGLTAPNGPSQQRVIRAALASARLRAVEVDVVEGHGTGTMLGDPIEAQALLATYGQD
RVEPLWLGSIKSNIGHTSAAAGVAGVIKMVQAMRHGVMPKTLHVDVPTPHVDWSVGAVSL
LTQPRAWSVHGRPRRAGVSSFGISGTNAHVILEQAPVVESVVPEVASPTAASAVPWVLSA
RSEQALAGQAQRLLAFVAANPDLDPIDVGWSLVKTRAMFEHRAVVVGADRGALLAGLAAL
AAGESGAGVAVGRARSVGKTVFVFPGQGAQWVGMGAQLYAELPLFALAFDAVAEELDRHL
RLPLRNVLWEGDEALLTSTEFAQPALFAIEVALATLLQHWGISPDFLIGHSVGEIAAAHL
AGVLSLTDAAGLVAARGRLMAELPAGGVMVVVAASEEEVLPVLVDGANLAAVNAPHSVVV
SGCEAAVSDIADHFARRGRRVHRLAVSHAFHSLLMEPMLAEFTRIAAGISVSKPRIPLVS
NVTGQMAGAGYGDGQYWVEHARRPVRFAEGVQLLNAVGATRFVEVGPGGGLTALVEQSLP
LGEALSVAMMRREHPEVSSVLGAVATLFTAGAQMDWPAVFGSPGRRIELPTYAFQRQRYW
LPPTSAGSADISGVGLLAARHGLLGAVVEQPDSDVVVLTGRLSVGEQRWLADHVIAGVVL
LAGAAFVELALRAADQVDCGVVEELTVVTPLVLPTVGGVQLQVVVGVGEMGQRPVSIYSR
NAESDSGWVLHARGVLGAKAVAPAADLSVWPPLGAAPVDVDGAYQRFAELGYEYGRAFQG
LTAMWRRESELFADVAVPDDVDVTLSGFGIHPLVLDAALHAMGMVGEQAATMLPFSWQGV
SLHAAGASRVRARIAPAGDGTVSVELADQAGLPVLSVQALVMRSVSSQLLSAAVAAADAA
GRGLLEVAWLPVELAHNDISADLVVWELESFQDGVGPVYSATHRVLVALQSWLAQERAGR
LVVLTQGSVGQDATNLAGAAVWGLVRSAQAEHPGRVMLVDSDGSMDVGDVIGCGEEQLMI
RNGTAYAARLAQLRPQPILQLPDTNSGWRLVAGGAGALEDLTLASCPAKELAPGQVRIEV
RALGVNFRDVLVALGIYPGAAELGAEGAGVVTEVGPGVTGLAVGDPVMGLLGVAGSEAVV
DARLVVKLPNRWPLTDAAGVPVVFLTAYYALRVLAQVQPGESVLVHAAAGGVGMAAVQLA
RLWGLEVFATASRGKWDTLHTMGCDNTHVADSRTLAFEETFWLTTEGRGVDVVLNSLAGE
FTDASLRLLPRGGRFIEMGKTEFGTPRSLPRTILGWPTGLST