Protein Info for Rv1603 in Mycobacterium tuberculosis H37Rv
Annotation: Probable phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase HisA
These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.
Protein Families and Features
Best Hits
Swiss-Prot: 100% identical to HIS4_MYCBT: Phosphoribosyl isomerase A (priA) from Mycobacterium bovis (strain BCG / Tokyo 172 / ATCC 35737 / TMC 1019)
KEGG orthology group: K01814, phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase [EC: 5.3.1.16] K01817, phosphoribosylanthranilate isomerase [EC: 5.3.1.24] (inferred from 100% identity to mtf:TBFG_11619)Predicted SEED Role
"Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase (EC 5.3.1.16) / Acting phosphoribosylanthranilate isomerase (EC 5.3.1.24)" in subsystem Tryptophan synthesis or Histidine Biosynthesis (EC 5.3.1.16, EC 5.3.1.24)
MetaCyc Pathways
- superpathway of histidine, purine, and pyrimidine biosynthesis (43/46 steps found)
- superpathway of aromatic amino acid biosynthesis (18/18 steps found)
- superpathway of L-tryptophan biosynthesis (13/13 steps found)
- L-histidine biosynthesis (10/10 steps found)
- L-tryptophan biosynthesis (6/6 steps found)
- superpathway of chorismate metabolism (40/59 steps found)
KEGG Metabolic Maps
- Biosynthesis of alkaloids derived from histidine and purine
- Biosynthesis of alkaloids derived from shikimate pathway
- Biosynthesis of phenylpropanoids
- Biosynthesis of plant hormones
- Histidine metabolism
- Phenylalanine, tyrosine and tryptophan biosynthesis
Isozymes
No predicted isozymesUse Curated BLAST to search for 5.3.1.16 or 5.3.1.24
Sequence Analysis Tools
PaperBLAST (search for papers about homologs of this protein)
Search CDD (the Conserved Domains Database, which includes COG and superfam)
Predict protein localization: PSORTb (Gram-negative bacteria)
Predict transmembrane helices and signal peptides: Phobius
Check the current SEED with FIGfam search
Find homologs in fast.genomics or the ENIGMA genome browser
Find the best match in UniProt
Protein Sequence (245 amino acids)
>Rv1603 Probable phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase HisA (Mycobacterium tuberculosis H37Rv) VMPLILLPAVDVVEGRAVRLVQGKAGSQTEYGSAVDAALGWQRDGAEWIHLVDLDAAFGR GSNHELLAEVVGKLDVQVELSGGIRDDESLAAALATGCARVNVGTAALENPQWCARVIGE HGDQVAVGLDVQIIDGEHRLRGRGWETDGGDLWDVLERLDSEGCSRFVVTDITKDGTLGG PNLDLLAGVADRTDAPVIASGGVSSLDDLRAIATLTHRGVEGAIVGKALYARRFTLPQAL AAVRD