Protein Info for Rv1527c in Mycobacterium tuberculosis H37Rv

Annotation: Probable polyketide synthase Pks5

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 200 400 600 800 1000 1200 1400 1600 1800 2000 2108 PF00109: ketoacyl-synt" amino acids 16 to 263 (248 residues), 313.2 bits, see alignment E=9.4e-97 PF00108: Thiolase_N" amino acids 168 to 215 (48 residues), 29.4 bits, see alignment (E = 3.4e-10) PF02801: Ketoacyl-synt_C" amino acids 271 to 384 (114 residues), 131.7 bits, see alignment 9.1e-42 PF16197: KAsynt_C_assoc" amino acids 395 to 503 (109 residues), 40.7 bits, see alignment 1.8e-13 PF00698: Acyl_transf_1" amino acids 546 to 862 (317 residues), 358 bits, see alignment E=3.8e-110 PF21089: PKS_DH_N" amino acids 905 to 996 (92 residues), 86.6 bits, see alignment (E = 6.4e-28) PF14765: PS-DH" amino acids 1034 to 1187 (154 residues), 79.2 bits, see alignment 1.7e-25 PF08240: ADH_N" amino acids 1446 to 1512 (67 residues), 28.4 bits, see alignment (E = 8.2e-10) PF00107: ADH_zinc_N" amino acids 1570 to 1685 (116 residues), 75.4 bits, see alignment 2.6e-24 PF13602: ADH_zinc_N_2" amino acids 1603 to 1741 (139 residues), 70.9 bits, see alignment 1.4e-22 PF08659: KR" amino acids 1765 to 1942 (178 residues), 194.7 bits, see alignment E=8.8e-61 PF00106: adh_short" amino acids 1768 to 1924 (157 residues), 34.3 bits, see alignment 1.1e-11 PF00550: PP-binding" amino acids 2029 to 2093 (65 residues), 32.5 bits, see alignment (E = 5.4e-11)

Best Hits

Swiss-Prot: 100% identical to PKS5_MYCTU: Mycocerosic acid synthase-like polyketide synthase (pks5) from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)

KEGG orthology group: K12433, polyketide synthase 5 (inferred from 100% identity to mbb:BCG_1579c)

Predicted SEED Role

"Polyketide synthase Pks2"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (2108 amino acids)

>Rv1527c Probable polyketide synthase Pks5 (Mycobacterium tuberculosis H37Rv)
VGKERTKTVDRTRVTPVAVIGMGCRLPGGIDSPDRLWEALLRGDDLVTEIPADRWDIDEY
YDPEPGVPGRTDCKWGAYLDNVGDFDPEFFGIGEKEAIAIDPQHRLLLETSWEAMEHGGL
TPNQMASRTGVFVGLVHTDYILVHADNQTFEGPYGNTGTNACFASGRVAYAMGLQGPAIT
VDTACSSGLTAIHLACRSLHDGESDIALAGGVYVMLEPRRFASGSALGMLSATGRCHAFD
VSADGFVSGEGCVMLALKRLPDALADGDRILAVIRGTAANQDGHTVNIATPSRSAQVAAY
REALDVAGVDPATVGMVEAHGPGTPVGDPIEYASLAEVYGNDGPCALASVKTNFGHTQSA
AGALGLMKAVLALQHGVVPQNLHFTALPDKLAAIETNLFVPQEITPWPGADQETPRRAAV
SSYGMTGTNVHAIVEQAPVPAPESGAPGDTPATPGIDGALLFALSASSQDALRQTAARLA
DWVDAQGPELAPADLAYTLARRRGHRPVRTAVLAATTAELTEALREVATGEPPYPPAVGQ
DDRGPVWVFSGQGSQWAGMGADLLATEPVFAATIAAIEPLIAAESGFSVTEAMTAPEVVT
GIDRVQPTLFAMQVALAATMKSYGVAPGAVIGHSLGESAAAVVAGALCLEDGVRVICRRS
ALMTRIAGAGAMASVELPAQQVLSELMARGVNDAVVAVVASPQSTVIGGATQTVRDLVAA
WEQRDVLAREVAVDVASHSPQVDPILDELAEALAEISPLQPEIPYYSATSFDPREEPYCD
AYYWVDNLRHTVRFAAAVQAALEDGYRVFTELTPHPLLTHAVDQTARSLDMSAAALAGMR
REQPLPHGLRALAGDLYAAGAAVDFAVLYPTGRLINAPLPTWNHRRLLLDDTTRRIAHAN
TVAVHPLLGSHVRLPEEPERHVWQGEVGTVTQPWLADHQIHGAAALPGAAYCEMALAAAR
AVLGEASEVRDIRFEQMLLLDDETPIGVTATVEAPGVVPLTVETSHDGRYTRQLAAVLHV
VREADDAPDQPPQKNIAELLASHPHKVDGAEVRQWLDKRGHRLGPAFAGLVDAYIAEGAG
DTVLAEVNLPGPLRSQVKAYGVHPVLLDACFQSVAAHPAVQGMADGGLLLPLGVRRLRSY
GSARHARYCCTTVTACGVGVEADLDVLDEHGAVVLAVRGLQLGTGASQASERARVLGERL
LSIEWHERELPENSHAEPGAWLLISTCDATDLVAAQLTDALKVHDAQCTTMSWPQRADHA
AQAARLRDQLGTGGFTGVFVLTAPQTGDPDAESPVRGGELVKHVVRIAREIPEITAQEPR
LYVLTHNAQAVLSGDRPNLEQGGMRGLLRVIGAEHPHLKASYVDVDEQTGAESVARQLLA
ASGEDETAWRNDQWYTARLCPAPLRPEERQTTVVDHAEAGMRLQIRTPGDLQTLEFAAFD
RVPPGPGEIEVAVTASSINFADVLVTFGRYQTLDGRQPQLGTDFAGVVSAVGPGVSELKV
GDRVGGMSPNGCWATFVTCDARLATRLPEGLTDAQAAAVTTASATAWYGLQDLARIKAGD
KVLIHSATGGVGQAAIAIARAAGAQIYATAGNEKRRDLLRDMGIEHVYDSRSVEFAEQIR
RDTAGYGVDIVLNSVTGAAQLAGLKLLALGGRFIEIGKRDIYSNTRLELLPFRRNLAFYG
LDLGLMSVSHPAAVRELLSTVYRLTVEGVLPMPQSTHYPLAEAATAIRVMGAAEHTGKLI
LDVPHAGRSSVVLPPEQARVFRSDGSYIITGGLGGLGLFLAEKMANAGAGRIVLSSRSQP
SQKALETIELVRAIGSDVVVECGDIAQPDTADRLVTAATATGLPLRGVLHAAAVVEDATL
ANITDELIERDWAPKAYGAWQLHRATADQPLDWFCSFSSAAALVGSPGQGAYAAANSWLD
TFTHWRRAQDLPATSIAWGAWGQIGRAIAFAEQTGDAIAPEEGAYAFETLLRHNRAYSGY
APVIGSPWLTAFAQHSPFAEKFQSLGQNRSGTSKFLAELVDLPREEWPDRLRRLLSKQVG
LILRRTIDTDRLLSEYGLDSLSSQELRARVEAETGIRISATEINTTVRGLADLMCDKLAA
DRDAPAPA