Protein Info for Rv1522c in Mycobacterium tuberculosis H37Rv

Annotation: Probable conserved transmembrane transport protein MmpL12

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 100 200 300 400 500 600 700 800 900 1000 1146 transmembrane" amino acids 21 to 42 (22 residues), see Phobius details amino acids 199 to 220 (22 residues), see Phobius details amino acids 223 to 227 (5 residues), see Phobius details amino acids 253 to 274 (22 residues), see Phobius details amino acids 295 to 318 (24 residues), see Phobius details amino acids 330 to 353 (24 residues), see Phobius details amino acids 382 to 404 (23 residues), see Phobius details amino acids 826 to 843 (18 residues), see Phobius details amino acids 850 to 875 (26 residues), see Phobius details amino acids 881 to 902 (22 residues), see Phobius details amino acids 922 to 945 (24 residues), see Phobius details amino acids 954 to 974 (21 residues), see Phobius details TIGR00833: transport protein" amino acids 22 to 988 (967 residues), 1407.3 bits, see alignment E=0 PF03176: MMPL" amino acids 57 to 382 (326 residues), 350.3 bits, see alignment E=4.7e-109 amino acids 676 to 1019 (344 residues), 293.9 bits, see alignment E=6.8e-92

Best Hits

Swiss-Prot: 100% identical to MMPLC_MYCTO: Probable transport protein MmpL12 (mmpL12) from Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)

KEGG orthology group: K06994, putative drug exporter of the RND superfamily (inferred from 100% identity to mtu:Rv1522c)

Predicted SEED Role

"Putative membrane protein MmpL12"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (1146 amino acids)

>Rv1522c Probable conserved transmembrane transport protein MmpL12 (Mycobacterium tuberculosis H37Rv)
VARHDEAKAGGLFDRIGNFVVRWPLIVIGCWIAVAAALTLLLPTLQAQAAKREQAPLPPG
APSMVLQKEMSAAFQEKIETSALLLVLLTNENGLGPADEAVYRKLIENLRADTQDKISVQ
DFLAVPEMKELLASKDNKAWNLPITFAGDAASPETQAAFKRVAAIVKQTVAGTSLTVHLS
GPIATVADLTELGEKDVRIIEIGTAVSVLIILILVYRNLVTMLVPLATIGASVVTAQGTL
SGLAEFGLAVNMQAIVFMSAVMIGAGTDYAVFLISRYHDYVRHGEKSDMAVKKALMSIGK
VITASAATVAVTFLAMVFTKLEVFSAVGPAIAVAITVSLLGAVTLLPAILTLTGRRGWIK
PRRDLTSRMWRRSGVRIVRRSTIHLVGSLIVLVALAGCTLLIRFNYDDLKTVPQHVESVK
GYEAMNRHFPMNAMTPMVLFIKSPRDLRTPGALADIEMMSREIAELPNIVMVRGLTRPNG
EPLKETKVSFQAGEVGGKLDEATTLLEEHGGELDQLTGGAHQLADALAQIRNEINGAVAS
SSGIVNTLQAMMDLMGGDKTIRQLENASQYVGRMRALGDNLSGTVTDAEQIATWASPMVN
ALNSSPVCNSDPACRTSRAQLAAIVQAQDDGLLRSIRALAVTLQQTQEYQTLARTVSTLD
GQLKQVVSTLKAVDGLPTKLAQMQQGANALADGSAALAAGVQELVDQVKKMGSGLNEAAD
FLLGIKRDADKPSMAGFNIPPQIFSRDEFKKGAQIFLSADGHAARYFVQSALNPATTEAM
DQVNDILRVADSARPNTELEDATIGLAGVPTALRDIRDYYNSDMKFIVIATIVIVFLILV
ILLRALVAPIYLIGSVLISYLSALGIGTLVFQLILGQEMHWSLPGLSFILLVAIGADYNM
LLISRIRDESPHGIRIGVIRTVGSTGGVITSAGLIFAASMFGLVGASINTMAQAGFTIGI
GIVLDTFLVRTVTVPALTTMIGRANWWPSELGRDPSTPPTKADRWLRRVKGHRRKAPIPA
PKPPHTKVVRNTNGHASKAATKSVPNGKPADLAEGNGEYLIDHLRRHSLPLFGYAAMPAY
DVVDGVSKPNGDGAHIGKEPVDHLLGHSLPLFGLAGLPSYDRWDDTSIGEPAVGHAGSKP
DAKLST