Protein Info for Rv1410c in Mycobacterium tuberculosis H37Rv

Annotation: Aminoglycosides/tetracycline-transport integral membrane protein

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 518 signal peptide" amino acids 1 to 24 (24 residues), see Phobius details transmembrane" amino acids 47 to 65 (19 residues), see Phobius details amino acids 77 to 98 (22 residues), see Phobius details amino acids 109 to 129 (21 residues), see Phobius details amino acids 139 to 164 (26 residues), see Phobius details amino acids 170 to 189 (20 residues), see Phobius details amino acids 201 to 222 (22 residues), see Phobius details amino acids 234 to 252 (19 residues), see Phobius details amino acids 271 to 290 (20 residues), see Phobius details amino acids 310 to 329 (20 residues), see Phobius details amino acids 336 to 355 (20 residues), see Phobius details amino acids 377 to 398 (22 residues), see Phobius details amino acids 409 to 433 (25 residues), see Phobius details amino acids 470 to 493 (24 residues), see Phobius details PF07690: MFS_1" amino acids 14 to 424 (411 residues), 134.9 bits, see alignment E=5e-43 PF06609: TRI12" amino acids 15 to 190 (176 residues), 31 bits, see alignment E=1.5e-11 PF00083: Sugar_tr" amino acids 45 to 185 (141 residues), 39.3 bits, see alignment E=6e-14

Best Hits

Swiss-Prot: 100% identical to MFS55_MYCTK: Probable triacylglyceride transporter TBMG_02570 (TBMG_02570) from Mycobacterium tuberculosis (strain KZN 1435 / MDR)

KEGG orthology group: None (inferred from 100% identity to mtb:TBMG_02570)

Predicted SEED Role

"Multidrug efflux pump P55"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (518 amino acids)

>Rv1410c Aminoglycosides/tetracycline-transport integral membrane protein (Mycobacterium tuberculosis H37Rv)
MRAGRRVAISAGSLAVLLGALDTYVVVTIMRDIMNSVGIPINQLHRITWIVTMYLLGYIA
AMPLLGRASDRFGRKLMLQVSLAGFIIGSVVTALAGHFGDFHMLIAGRTIQGVASGALLP
ITLALGADLWSQRNRAGVLGGIGAAQELGSVLGPLYGIFIVWLLHDWRDVFWINVPLTAI
AMVMIHFSLPSHDRSTEPERVDLVGGLLLALALGLAVIGLYNPNPDGKHVLPDYGAPLLV
GALVAAVAFFGWERFARTRLIDPAGVHFRPFLSALGASVAAGAALMVTLVDVELFGQGVL
QMDQAQAAGMLLWFLIALPIGAVTGGWIATRAGDRAVAFAGLLIAAYGYWLISHWPVDLL
ADRHNILGLFTVPAMHTDLVVAGLGLGLVIGPLSSATLRVVPSAQHGIASAAVVVARMTG
MLIGVAALSAWGLYRFNQILAGLSAAIPPNASLLERAAAIGARYQQAFALMYGEIFTITA
IVCVFGAVLGLLISGRKEHADEPEVQEQPTLAPQVEPL