Protein Info for Rv1290c in Mycobacterium tuberculosis H37Rv

Annotation: Conserved protein

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 521 transmembrane" amino acids 67 to 93 (27 residues), see Phobius details amino acids 113 to 139 (27 residues), see Phobius details amino acids 158 to 179 (22 residues), see Phobius details amino acids 192 to 212 (21 residues), see Phobius details PF10011: DUF2254" amino acids 69 to 438 (370 residues), 346.7 bits, see alignment E=7.3e-108

Best Hits

Swiss-Prot: 100% identical to Y1321_MYCBO: Uncharacterized protein Mb1321c (BQ2027_MB1321C) from Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97)

KEGG orthology group: None (inferred from 100% identity to mra:MRA_1298)

Predicted SEED Role

"FIG00820284: hypothetical protein"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (521 amino acids)

>Rv1290c Conserved protein (Mycobacterium tuberculosis H37Rv)
VLQRSLGVNGRKLAMSARSAKRERKNASTAASKCYVVPPSARGWVHAYSVTATSMLNRRK
AILDYLQGAVWVLPTFGVAIGLGSGAVLSMIPVKSGTLIDKLMFQGTPGDARGVLIVVSA
TMITTIGIVFSLTVLSLQIASSQFSVRLLRTFLRDVPNQVVLAIFACTFAYSTGGLHTVG
EHRDGGAFIPKVAVTGSLALAFVSIAALIYFLHHLMHSIQIDTIMDKVRLRTLGLVDQLY
PESDTADRQVETPPSPPADAVPLLAPHSGYLQTVDVDDIAELAAASRYTALLVTFVGDYV
TAGGLLGWCWRRGTAPGAPGSDFPQRCLRHVHIGFERTLQQDIRFGLRQMVDIALRALSP
ALNDPYTAIQVVHHLSAVESVLASRALPDDVRRDRAGELLFWLPYPSFATYLHVGCAQIR
RYGSREPLVLTALLQLLSAVAQNCVDPSRRVAVQTQIALVVRAAQREFADESDRAMVLGA
AARATEVVERPGTLAPPPSTFGQVAAAQAAASTIRSADRDG